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Increased salt-sensitivity in endothelial nitric oxide synthase–knockout mice

Leonard, Allison M. ; Chafe, Linda L. ; Montani, Jean-Pierre ; Vliet, Bruce N. Van

In: American Journal of Hypertension, 2006, vol. 19, no. 12, p. 1264-1269

Background Although impaired nitric oxide production contributes importantly to salt- sensitivity, the role of the endothelial isoform of nitric oxide synthase (eNOS) has received little attention. In the present study we compared the effects of a high-salt diet on the blood pressure response of eNOS knockout (eNOS−/−) and control (eNOS+/+) mice. Methods Mean arterial pressure (MAP), heart...