In: Integrative Physiology, 2016, p. 227
Uninephrectomy (UniNX) in rats on a fixed food intake leads to increased lipolysis and a low-grade inflammation with an increased subset of circulating cytokines. Because UniNX ablates renal nerves on the side of the removed kidney, we tested the contribution of unilateral renal denervation in the phenotype of UniNX. We compared Sham-operated controls, left nephrectomy (UniNX) and unilateral...
|
In: American Journal of Physiology Regulatory, Integrative and Comparative Physiolology, 2010, p. -
Alterations in the circadian blood pressure pattern are frequently observed in hypertension and lead to increased cardiovascular morbidity. However, there are no studies that have investigated a possible implication of the Period2 gene, a key component of the molecular circadian clock, on the circadian rhythms of blood pressure and heart rate. To address this question, we monitored blood...
|
In: Experimental Physiology, 2009, vol. 94, no. 4, p. 396-397
|
In: Experimental Physiology, 2009, vol. 94, no. 4, p. 382-388
With the publication in 1972 of a large computer model of circulatory control, Guyton and colleagues challenged the then prevailing views on how blood pressure and cardiac output were controlled. At that time, it was widely accepted that the heart controlled cardiac output and that peripheral resistance controlled arterial blood pressure. By incorporating the empirically demonstrated concepts of...
|
In: American Journal of Physiology: Heart and Circulatory Physiology, 2007, vol. 293, p. H1265-H1272
hereas the sympathetic nervous system has a well-established role in blood pressure (BP) regulation, it is not clear whether long-term levels of BP are affected by parasympathetic function or dysfunction. We tested the hypothesis that chronic blockade of the parasympathetic nervous system has sustained effects on BP, heart rate (HR), and BP variability (BPV). Sprague-Dawley rats were...
|
In: American Journal of Hypertension, 2006, vol. 19, no. 12, p. 1264-1269
Background Although impaired nitric oxide production contributes importantly to salt- sensitivity, the role of the endothelial isoform of nitric oxide synthase (eNOS) has received little attention. In the present study we compared the effects of a high-salt diet on the blood pressure response of eNOS knockout (eNOS−/−) and control (eNOS+/+) mice. Methods Mean arterial pressure (MAP), heart...
|