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Université de Fribourg

Role of JNK activation in pancreatic β-cell death by streptozotocin

Cheon, Hwanju ; Cho, Jae Min ; Kim, Sunshin ; Baek, Seung-Hoon ; Lee, Moon-Kyu ; Kim, Kwang-Won ; Yu, Seong-Woon ; Solinas, Giovanni ; Kim, Soung Soo ; Lee, Myung-Shik

In: Molecular and Cellular Endocrinology, 2010, vol. 321, no. 2, p. 131-137

c-Jun N-terminal kinase (JNK) is activated by cellular stress and plays critical roles in diverse types of cell death. However, role of JNK in β-cell injury is obscure. We investigated the role for JNK in streptozotocin (STZ)-induced β-cell death. STZ induced JNK activation in insulinoma or islet cells. JNK inhibitors attenuated insulinoma or islet cell death by STZ. STZ-induced JNK activation...