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Molecular pathways linking metabolic inflammation and thermogenesis

Solinas, Giovanni

In: Obesity Review, 2012, vol. 13, no. S2, p. 69–82

Obesity is caused by chronic positive energy balance because of higher energy intake relative to energy expenditure. Thermogenesis, the capacity of an organism to produce heat, is an important component of energy expenditure. Thus targeting the molecular mechanisms controlling thermogenesis could be an effective strategy for the prevention or treatment of obesity. Thermogenesis is modulated by...

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Role of JNK activation in pancreatic β-cell death by streptozotocin

Cheon, Hwanju ; Cho, Jae Min ; Kim, Sunshin ; Baek, Seung-Hoon ; Lee, Moon-Kyu ; Kim, Kwang-Won ; Yu, Seong-Woon ; Solinas, Giovanni ; Kim, Soung Soo ; Lee, Myung-Shik

In: Molecular and Cellular Endocrinology, 2010, vol. 321, no. 2, p. 131-137

c-Jun N-terminal kinase (JNK) is activated by cellular stress and plays critical roles in diverse types of cell death. However, role of JNK in β-cell injury is obscure. We investigated the role for JNK in streptozotocin (STZ)-induced β-cell death. STZ induced JNK activation in insulinoma or islet cells. JNK inhibitors attenuated insulinoma or islet cell death by STZ. STZ-induced JNK activation...

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