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Université de Fribourg

Mutation of the circadian clock gene Per2 alters vascular endothelial function

Viswambharan, Hema ; Carvas, João Miguel ; Antic, Vladan ; Marecic, Ana ; Jud, Corinne ; Zaugg, Christian E. ; Ming, Xiu-Fen ; Montani, Jean-Pierre ; Albrecht, Urs ; Yang, Zhihong

In: Circulation, 2007, vol. 115, p. 2188-2195

Background— The circadian clock regulates biological processes including cardiovascular function and metabolism. In the present study, we investigated the role of the circadian clock gene Period2 (Per2) in endothelial function in a mouse model. Methods and Results— Compared with the wild-type littermates, mice with Per2 mutation exhibited impaired...