Université de Fribourg

Cardiovascular responses to sugary drinks in humans: galactose presents milder cardiac effects than glucose or fructose

Charrière, Nathalie ; Loonam, Cathriona ; Montani, Jean-Pierre ; Dulloo, Abdul G. ; Grasser, Erik K.

In: European Journal of Nutrition, 2017, vol. 56, no. 6, p. 2105–2113

PurposeThere is increasing interest into the potentially beneficial effects of galactose for obesity and type 2 diabetes management as it is a low-glycemic sugar reported to increase satiety and fat mobilization. However, fructose is also a low-glycemic sugar but with greater blood pressure elevation effects than after glucose ingestion. Therefore, we investigated here the extent to which the...

Université de Fribourg

Substantial inter-subject variability in blood pressure responses to glucose in a healthy, non-obese population

Monnard, Cathriona R. ; Fellay, Benoît ; Scerri, Isabelle ; Grasser, Erik K.

In: Frontiers in Physiology, 2017, vol. 8, p. -

Aim: A large inter-subject variability in the blood pressure (BP) response to glucose drinks has been reported. However, the underlying factors remain elusive and we hypothesized that accompanying changes in glucose metabolism affect these BP responses.Methods: Cardiovascular and glycemic changes in response to a standard 75 g oral-glucose-tolerance-test were investigated in 30 healthy, non-obese...

Université de Fribourg

QT interval shortening after bariatric surgery depends on the applied heart rate correction equation

Grasser, Erik K. ; Ernst, Barbara ; Thurnheer, Martin ; Schultes, Bernd

In: Obesity Surgery, 2017, vol. 27, no. 4, p. 973–982

A shortening of electrocardiographic QT interval has been observed in obese subjects after weight loss, but previous results may have been biased by inappropriate heart rate (HR) correction.Methods Electrocardiography (ECG) recordings of 49 (35 females) severely obese patients before and 12 months after Roux-en-Y gastric bypass (RYGB) surgery were analysed. QT interval (QTc) was calculated...

Université de Fribourg

Cerebro- and cardio-vascular responses to energy drink in young adults: Is there a gender effect?

Monnard, Cathríona R. ; Montani, Jean-Pierre ; Grasser, Erik K.

In: Integrative Physiology, 2016, p. 346

Background and Purpose: Energy drinks (EDs) are suspected to induce potential adverse cardiovascular effects and have recently been shown to reduce cerebral blood flow velocity (CBFV) in young, healthy subjects. Gender differences in CBFV in response to EDs have not previously been investigated, despite the fact that women are more prone to cardiovascular disturbances such as...

Université de Fribourg

Cardiovascular responses to the ingestion of sugary drinks using a randomised cross-over study design: does glucose attenuate the blood pressure-elevating effect of fructose?

Grasser, Erik K. ; Dulloo, Abdul ; Montani, Jean-Pierre

In: British Journal of Nutrition, 2014, vol. 112, no. 02, p. 183–192

Overconsumption of sugar-sweetened beverages has been implicated in the pathogenesis of CVD. The objective of the present study was to elucidate acute haemodynamic and microcirculatory responses to the ingestion of sugary drinks made from sucrose, glucose or fructose at concentrations similar to those often found in commercial soft drinks. In a randomised cross-over study design, twelve young...

Université de Fribourg

Cardio- and cerebrovascular responses to the energy drink Red Bull in young adults: a randomized cross-over study

Grasser, Erik K. ; Yepuri, Gayathri ; Dulloo, Abdul G. ; Montani, Jean-Pierre

In: European Journal of Nutrition, 2014, p. 1–11

Purpose: Energy drinks are beverages containing vasoactive metabolites, usually a combination of caffeine, taurine, glucuronolactone and sugars. There are concerns about the safety of energy drinks with some countries banning their sales. We determined the acute effects of a popular energy drink, Red Bull, on cardiovascular and hemodynamic variables, cerebrovascular parameters and microvascular...