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Substrate cycling between de novo lipogenesis and lipid oxidation: a thermogenic mechanism against skeletal muscle lipotoxicity and glucolipotoxicity

Dulloo, Abdul G. ; Gubler, Marcel ; Montani, Jean-Pierre ; Seydoux, Josiane ; Solinas, Giovanni

In: International Journal of Obesity, 2004, vol. 28 (Suppl. 4), p. S29-S37

Life is a combustion, but how the major fuel substrates that sustain human life compete and interact with each other for combustion has been at the epicenter of research into the pathogenesis of insulin resistance ever since Randle proposed a 'glucose-fatty acid cycle' in 1963. Since then, several features of a mutual interaction that is characterized by both reciprocality and dependency between...