Université de Fribourg

Role of mutation of the circadian clock gene Per2 in cardiovascular circadian rhythms

Vukolic, Ana ; Antic, Vladan ; Vliet, Bruce N. Van ; Yang, Zhihong ; Albrecht, Urs ; Montani, Jean-Pierre

In: American Journal of Physiology Regulatory, Integrative and Comparative Physiolology, 2010, p. -

Alterations in the circadian blood pressure pattern are frequently observed in hypertension and lead to increased cardiovascular morbidity. However, there are no studies that have investigated a possible implication of the Period2 gene, a key component of the molecular circadian clock, on the circadian rhythms of blood pressure and heart rate. To address this question, we monitored blood...

Université de Fribourg

Hemodynamic consequences of chronic parasympathetic blockade with a peripheral muscarinic antagonist

Ayer, Antoine ; Antic, Vladan ; Dulloo, Abdul G. ; Vliet, Bruce N. van ; Montani, Jean-Pierre

In: American Journal of Physiology: Heart and Circulatory Physiology, 2007, vol. 293, p. H1265-H1272

hereas the sympathetic nervous system has a well-established role in blood pressure (BP) regulation, it is not clear whether long-term levels of BP are affected by parasympathetic function or dysfunction. We tested the hypothesis that chronic blockade of the parasympathetic nervous system has sustained effects on BP, heart rate (HR), and BP variability (BPV). Sprague-Dawley rats were...

Université de Fribourg

Mutation of the circadian clock gene Per2 alters vascular endothelial function

Viswambharan, Hema ; Carvas, João Miguel ; Antic, Vladan ; Marecic, Ana ; Jud, Corinne ; Zaugg, Christian E. ; Ming, Xiu-Fen ; Montani, Jean-Pierre ; Albrecht, Urs ; Yang, Zhihong

In: Circulation, 2007, vol. 115, p. 2188-2195

Background— The circadian clock regulates biological processes including cardiovascular function and metabolism. In the present study, we investigated the role of the circadian clock gene Period2 (Per2) in endothelial function in a mouse model. Methods and Results— Compared with the wild-type littermates, mice with Per2 mutation exhibited impaired...

Université de Fribourg

Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases

Montani, Jean-Pierre ; Carroll, Joan F. ; Dwyer, Terry M. ; Antic, Vladan ; Yang, Zhihong ; Dulloo, Abdul G.

In: International Journal of Obesity, 2004, vol. 28, p. S58-65

In humans and most animal models, the development of obesity leads not only to increased fat depots in classical adipose tissue locations but also to significant lipid deposits within and around other tissues and organs, a phenomenon known as ectopic fat storage. The purpose of this review is to explore the possible locations of ectopic fat in key target-organs of cardiovascular control (heart,...