Université de Neuchâtel

A microelectrode array (MEA) integrated with clustering structures for investigating in vitro neurodynamics in confined interconnected sub-populations of neurons

Berdondini, Luca ; Chiappalone, M. ; van der Wal, P.D. ; Imfeld, Kilian ; de Rooij, Nicolaas F. ; Koudelka-Hep, Milena ; Tedesco, M. ; Martinoia, S. ; van Pelt, J. ; Le Masson, G. ; Garenne, A.

In: Sensors and Actuators B : Chemical, 2006, vol. 114, no. 1, p. 530-541

Understanding how the information is coded in large neuronal networks is one of the major challenges for neuroscience. A possible approach to investigate the information processing capabilities of the neuronal ensembles is given by the use of dissociated neuronal cultures coupled to microelectrode arrays (MEAs). Here, we describe a new strategy, based on MEAs, for studying in vitro...

Université de Neuchâtel

High-density electrode array for imaging in vitro electrophysiological activity

Berdondini, Luca ; van der Wal, P.D. ; Guenat, Olivier ; de Rooij, Nicolaas F. ; Koudelka-Hep, Milena ; Seitz, P. ; Kaufmann, R. ; Metzler, P. ; Blanc, N. ; Rohr, S.

In: Biosensors and Bioelectronics, 2005, vol. 21, no. 1, p. 167

The development of a high-density active microelectrode array for in vitro electrophysiology is reported. Based on the Active Pixel Sensor (APS) concept, the array integrates 4096 gold microelectrodes (electrode separation 20 μm) on a surface of 2.5 mm × 2.5 mm as well as a high-speed random addressing logic allowing the sequential selection of the measuring pixels. Following the electrical...