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Model peptide studies of Ag+ binding sites from the silver resistance protein SilE

Chabert, Valentin ; Hologne, M. ; Sénèque, O. ; Crochet, Aurélien ; Walker, O. ; Fromm, Katharina M.

In: Chemical Communications, 2017, vol. 53, no. 45, p. 6105–6108

Using model peptides, each of the nine MX2H or HXnM (n = 1, 2) motifs of the silver resistance protein SilE has been shown to coordinate to one Ag+ ion by its histidine and methionine residues with Kd in the μM range. This suggests an Ag+ buffering role for SilE in the case of high Ag+ overload.