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Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis

Piccoli, Luca ; Campo, Ilaria ; Fregni, Chiara Silacci ; Fernandez Rodriguez, Blanca Maria ; Minola, Andrea ; Sallusto, Federica ; Luisetti, Maurizio ; Corti, Davide ; Lanzavecchia, Antonio

In: Nature communications, 2015, vol. 6, p. 7375

Pulmonary alveolar proteinosis (PAP) is a severe autoimmune disease caused by autoantibodies that neutralize GM-CSF resulting in impaired function of alveolar macrophages. In this study, we characterize 21 GM-CSF autoantibodies from PAP patients and find that somatic mutations critically determine their specificity for the self-antigen. Individual antibodies only partially neutralize GM-CSF...