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Developing swiss paraplegic research: Building a research institution from the comprehensive perspective

Stucki, Gerold ; Reinhardt, Jan D. ; Cieza, Alarcos ; Brach, Mirjam ; Celio, Marco R. ; Joggi, Daniel ; Villiger, Beat ; Zäch, Guido A. ; Krieg, Walter

In: Disability & Rehabilitation, 2008, vol. 30, no. 14, p. 1063 - 1078

Purpose. To illustrate the conceptualization and development of a research institution from the comprehensive perspective based on the integrative model of functioning provided by the World Health Organization's (WHO) International Classification of Functioning, Disability and Health (ICF). The newly founded research institution Swiss Paraplegic Research which focuses on the comprehensive study...

Laparoscopic training on Thiel human cadavers: A model to teach advanced laparoscopic procedures

Frésard, Isabelle ; Häfliger, André ; Bergmann, Mathias ; Krähenbühl, Lukas

In: Surgical Endoscopy, 2008, vol. 22, no. 4, p. 901-906

Background: Nowadays, the laparoscopic approach represents the gold standard for a wide range of various basic and advanced procedures. To reduce the learning curve in advanced laparoscopic surgery, the search for new teaching tools is of utmost importance. Our experiences with a new teaching tool to train advanced laparoscopic procedures are reported. Methods: Hands-on training courses in...

Effects of early second language acquisition on the cortical language network in multilinguals : evidence from fMRI

Wattendorf, Elise ; Rager, Günter (Dir.)

Thèse de doctorat : Université de Fribourg, 2006.

Research on language acquisition has shown that language development depends on language experience during early childhood. Early acquisition of one as opposed to two languages should therefore influence the development of language capabilities. Various psycholinguistic studies have provided support for this idea. The impact of early second language acquisition on the establishment of the...

Hematopoietic regulation by catecholamines

Togni, Mauro ; Dreyer, Jean-Luc (Dir.)

Thèse de doctorat : Université de Fribourg, 2000 ; no 1284.

The tip60 HAT-complex is recruited to chromatin by the transcription factors E2F and Myc

Taubert, Stefan ; Conzelmann, Andreas (Dir.)

Thèse de doctorat : Université de Fribourg, 2003 ; no 1409.

The oncogenic transcription factors E2F and Myc bind to specific DNA sequences at distinct times during the G1 phase of the mammalian cell cycle, and regulate transcription of a plethora of target genes. E2F and Myc associate with TRRAP, a subunit of distinct macromolecular complexes that contain the histone acetyltransferases (HATs) Gcn5/PCAF or Tip60. During the course of my thesis I...

Interaction of Per and Cry genes in the mammalian circadian clock

Oster, Henrik ; Albrecht, Urs (Dir.)

Thèse de doctorat : Université de Fribourg, 2002 ; Nr. 1396.

To cope with the daily changes in their environment, in organisms, from cyanobacteria to humans, endogenous clocks have evolved that anticipate these changes and synchronize physiology and behavior accordingly. In mammals, the central circadian pacemaker is located in the suprachiasmatic nuclei (SCN) of the hypothalamus. From there subordinated cellular clocks in the peripheral organs are...

Substrate cycling between de novo lipogenesis and lipid oxidation: a thermogenic mechanism against skeletal muscle lipotoxicity and glucolipotoxicity

Dulloo, Abdul G. ; Gubler, Marcel ; Montani, Jean-Pierre ; Seydoux, Josiane ; Solinas, Giovanni

In: International Journal of Obesity, 2004, vol. 28 (Suppl. 4), p. S29-S37

Life is a combustion, but how the major fuel substrates that sustain human life compete and interact with each other for combustion has been at the epicenter of research into the pathogenesis of insulin resistance ever since Randle proposed a 'glucose-fatty acid cycle' in 1963. Since then, several features of a mutual interaction that is characterized by both reciprocality and dependency between...

Functional analysis of the yeast "Saccharomyces cerevisiae" Gpi8 protein and characterization of the purified GPI-transamidase complex

Fraering, Patrick ; Conzelmann, Andreas (Dir.) ; van der Goot, Françoise Gisou (Codir.) ; Puoti, Alessandro (Codir.)

Thèse de doctorat : Université de Fribourg, 2001 ; no 1354.

Dans le monde des Eucaryotes inférieurs ou supérieurs, de nombreuses glycoprotéines sont ancrées dans leur membrane plasmique par l’intermediaire d’une ancre GPI (glycosylphosphatidylinositol). Cette modification post-traductionnelle est nécessaire pour la croissance et le développement de la levure Saccharomyces cerevisiae. Chez cet organisme, environ 70 cadres ouverts de lecture...

Understanding apoptosis involved in the development and treatment of malignancies

Genini, Davide ; Rusconi, Sandro (Dir.) ; Martinou, Jean-Claude (Codir.) ; Leoni, Lorenzo (Codir.)

Thèse de doctorat : Université de Fribourg, 2000 ; nr. 1321.

L’apoptose (ou mort cellulaire programmée) est un processus cellulaire essentiel présent dans la majorité des organismes. Afin de préserver l’homéostase des tissus, un nombre comparable de cellules doit mourir pour maintenir l'équilibre avec les cellules produites par mitose. Cependant, dans de nombreuses maladies (en particulier le cancer), ce méchanisme de mort cellulaire est...

Tenascin-R and perineuronal nets of extracellular matrix

Haunsø, Anders Kristian ; Menoud, Pierre-Alain (Dir.) ; Celio, Marco (Codir.)

Thèse de doctorat : Université de Fribourg, 2000 ; no 1307.

La tenascine-R (TN-R) est une glycoprotéine de la matrice extracellulaire du cerveau (Zamze et al., 1999) dont la distribution est restreinte au système nerveux central. (Pesheva et al., 1989; Rathjen et al., 1991; Weber et al., 1999) Une des caractéristiques de la TN-R et de quelques-uns de ses ligands connus, est son accumulation autour de certaines sous-population de neurones, formant ainsi...