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Université de Fribourg

European practical and patient-centred guidelines for adult obesity management in primary care

Durrer Schutz, D. ; Busetto, L. ; Dicker, D. ; Farpour-Lambert, N. ; Pryke, R. ; Toplak, H. ; Widmer, D. ; Yumuk, V. ; Schutz, Yves

In: Obesity Facts, 2019, vol. 12, no. 1, p. 40–66

The first contact for patients with obesity for any medical treatment or other issues is generally with General Practitioners (GPs). Therefore, given the complexity of the disease, continuing GPs’ education on obesity management is essential. This article aims to provide obesity management guidelines specifically tailored to GPs, favouring a practical patient-centred approach. The focus is...

Università della Svizzera italiana

Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine

Corti, Davide ; Suguitan Jr., Amorsolo ; Pinna, Debora ; Silacci, Chiara ; Fernandez-Rodriguez, Blanca M. ; Vanzetta, Fabrizia ; Santos, Celia ; Luke, Catherine J. ; Torres-Velez, Fernando J. ; Temperton, Nigel J. ; Weiss, Robin A. ; Sallusto, Federica ; Subbarao, Kanta ; Lanzavecchia, Antonio

In: The Journal of clinical investigation, 2010, vol. 120, no. 5, p. 1663-1673

The target of neutralizing antibodies that protect against influenza virus infection is the viral protein HA. Genetic and antigenic variation in HA has been used to classify influenza viruses into subtypes (H1–H16). The neutralizing antibody response to influenza virus is thought to be specific for a few antigenically related isolates within a given subtype. However, while heterosubtypic...

Università della Svizzera italiana

Polarization of migrating monocytic cells is independent of PI 3-Kinase activity

Volpe, Silvia ; Thelen, Sylvia ; Pertel. Thomas ; Lohse, Martin J. ; Thelen, Marcus

In: Plos one, 2010, vol. 5, no. 4, p. e10159

Background: Migration of mammalian cells is a complex cell type and environment specific process. Migrating hematopoietic cells assume a rapid amoeboid like movement when exposed to gradients of chemoattractants. The underlying signaling mechanisms remain controversial with respect to localization and distribution of chemotactic receptors within the plasma membrane and the role of PI 3-kinase...

Università della Svizzera italiana

CXCR7 functions as a scavenger for CXCL12 and CXCL11

Naumann, Ulrike ; Cameroni, Elisabetta ; Pruenster, Monika ; Mahabaleshwar, Harsha ; Raz, Erez ; Zerwes, Hans-Günter ; Rot, Antal ; Thelen, Marcus

In: Plos one, 2010, vol. 5, no. 2, p. e9175

Background: CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses. The function of CXCR7 is controversial. Some studies suggest a signaling activity in mammalian cells and zebrafish embryos, while others indicate a decoy...

Università della Svizzera italiana

Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals

Corti, Davide ; Langedijk, Johannes P. M. ; Hinz, Andreas ; Seaman, Michael S. ; Vanzetta, Fabrizia ; Fernandez-Rodriguez, Blanca M. ; Silacci, Chiara ; Pinna, Debora ; Jarrossay, David ; Balla-Jhagjhoorsingh, Sunita ; Willems, Betty ; Zekveld, Maria J. ; Dreja ; O’Sullivan, Eithne ; Pade, Corinna ; Orkin, Chloe ; Jeffs, Simon A. ; Montefiori, David C. ; David, Davis ; Weissenhorn, Winfried ; McKnight, Aine ; Heeney, Jonathan L. ; Sallusto, Federica ; Sattentau, Quentin J. ; Weiss, robin A. ; Lanzavecchia, Antonio

In: Plos one, 2010, vol. 5, no. 1, p. e8805

Background The isolation of human monoclonal antibodies (mAbs) that neutralize a broad spectrum of primary HIV-1 isolates and the characterization of the human neutralizing antibody B cell response to HIV-1 infection are important goals that are central to the design of an effective antibody-based vaccine. Methods and Findings We immortalized IgG+ memory B cells from individuals infected with...

Haute Ecole d'Ingénierie

Installation d’instrument par drone (InstalloDrone)

Gillioz, Loïc ; Moerschell, Joseph (Dir.)

Mémoire de bachelor : Haute Ecole d'Ingénierie, 2018.

Les instruments de mesure environnementaux doivent souvent être installés dans des zones à risque. Ce projet cherche à développer un concept d'installation d'un appareil sur un rocher, avec un drone, pour réduire les risques et les coûts.

Haute Ecole d'Ingénierie

3D profile reconstruction

Briguet, Daniel ; Kandaswamy, Djano (Dir.)

Mémoire de bachelor : Haute Ecole d'Ingénierie, 2018.

The objective of the project is to develop a system to reconstruct in 3D the profile of a moving object.

Haute Ecole d'Ingénierie

Détection de victimes d’avalanches par drone

Bontempelli, Vincent ; Roduit, Pierre (Dir.)

Mémoire de bachelor : Haute Ecole d'Ingénierie, 2018.

Le but de ce projet est de déterminer les possibilités et l’efficacité de l’utilisation d’un drone lors d’une recherche de victimes avalanches.

Haute Ecole d'Ingénierie

Mobilité flexible

Arumugam, Mariatharsan ; Morand, Gilbert (Dir.)

Mémoire de bachelor : Haute Ecole d'Ingénierie, 2018.

Développer un outil informatique d’aide à la décision qui joue des scénarios liés à la mobilité. Le logiciel met en oeuvre des techniques dites de «Monte-Carlo» pour générer en sortie un tableau de bord groupant divers indicateurs de performance de mobilité.

Université de Fribourg

On Split B1-EPG Graphs

Deniz, Zakir ; Nivelle, Simon ; Ries, Bernard ; Schindl, David

In: Lecture Notes in Computer Science, 2018, vol. 10807, p. 361-375

We consider the following problem: can a certain graph parameter of some given graph G be reduced by at least d, for some integer d, via at most k graph operations from some specified set S, for some given integer k? As graph parameters we take the chromatic number and the clique number. We let the set S consist of either an edge contraction or a vertex deletion. As all these problems are...