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Université de Fribourg

Excitonic channels from bio-inspired templated supramolecular assembly of J-aggregate nanowires

Anantharaman, Surendra B. ; Messmer, Daniel ; Sadeghpour, Amin ; Salentinig, Stefan ; Nüescha, Frank ; Heier, Jakob

In: Nanoscale, 2019, vol. 11, no. 14, p. 6929–6938

Supramolecular assemblies with controlled morphology are of paramount importance for energy transport in organic semiconductors. Despite considerable freedom in molecular design, the preparation of dyes that form one dimensional J-aggregates is challenging. Here, we demonstrate a simple and effective route to functionalize dendronized polymers (DPs) with J-aggregates to construct tubular...

Université de Fribourg

Magneto-responsive cell culture substrates that can be modulated in situ

Crippa, Federica ; Rothen-Rutishauser, Barbara ; Petri-Fink, Alke

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 51–54

Understanding the interaction between cells and their environment is fundamental for mechanobiology. To mimic the behavior of cells in physiological and pathological conditions, synthetic substrates must have topographical and/or mechanical properties that evolve in time. Dynamic substrates mainly rely on stimuli-responsive materials where an external stimulus induces controlled variations in...

Université de Fribourg

A bio-inspired amplification cascade for the detection of rare cancer cells

Rüegg, Curzio ; Reis, Corine ; Rafiee, Sarah ; Rodriguez-Lorenzoa, Laura ; List, Jonathan ; Rothen-Rutishauser, Barbara ; Mayer, Michael ; Petri-Fink, Alke

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 63–68

The main cause of cancer-related death is due to cancer cell spreading and formation of secondary tumors in distant organs, the so-called metastases. Metastatic cancer cells are detectable in the blood of cancer patients as circulating tumor cells (CTC) and may be exploited for prognostic and monitoring purposes, including in breast cancer. Due to their very low frequency, however, their...

Université de Fribourg

Artificial lysosomal platform to study nanoparticle long-term stability

Milosevic, Ana ; Bourquin, Joël ; Burnand, David ; Lemal, Philipp ; Crippa, Federica ; Monnier, Christophe A. ; Rodriguez-Lorenzo, Laura ; Petri-Fink, Alke ; Rothen-Rutishauser, Barbara

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 55–58

Nanoparticles (NPs) possess unique properties useful for designing specific functionalities for biomedi- cal applications. A prerequisite of a safe-by-design and effective use in any biomedical application is to study NP–cell interactions to gain a better understanding of cellular consequences upon exposure. Cellular uptake of NPs results mainly in the localization of NPs in the complex...

Université de Fribourg

Structural insights into semicrystalline states of electrospun nanofibers: a multiscale analytical approach

Maurya, Anjani K. ; Weidenbacher, Lukas ; Spano, Fabrizio ; Fortunato, Giuseppino ; Rossi, René M. ; Frenz, Martin ; Dommann, Alex ; Neels, Antonia ; Sadeghpour, Amin

In: Nanoscale, 2019, vol. 11, no. 15, p. 7176–7187

A dedicated nanofiber design for applications in the biomedical domain is based on the understanding of nanofiber structures. The structure of electrospun nanofibers strongly influences their properties and functionalities. In polymeric nanofibers X-ray scattering and diffraction methods, i.e. SAXS and WAXD, are capable of decoding their structural insights from about 100 nm down to the...

Université de Fribourg

Functional polymers through mechanochemistry

Schrettl, Stephen ; Balkenendea, Diederik W. R. ; Calvino, Céline ; Karman, Marc ; Lavrenova, Anna ; Neumann, Laura N. ; Sagaraa, Yoshimitsu ; Verde-Sestoa, Ester ; Giannantonio, Michela di ; Simon, Yoan C. ; Fromm, Katharina M. ; Lattuada, Marco ; Weder, Christoph

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 7–11

While coupling mechanical and chemical processes is widespread in living organisms, the idea to harness the mechanically induced dissociation of weak covalent and non- covalent bonds to create artificial materials that respond to mechanical stimulation has only recently gained attention. Here we summarize our activities that mainly revolve around the exploitation of non-covalent interactions...

Université de Fribourg

Effect of clustering on the heat generated by superparamagnetic iron oxide nanoparticles

Lattuada, Marco

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 39–42

Magnetic nanoparticles have been the subject of enormous investigations for their potential use as cancer treatment via hyperthermia. This is due to their ability to generate heat when exposed to an external magnetic field oscillating at sufficiently high frequency. There are many different parameters that need to be considered when designing the optimal nanoparticle formulation for...

Université de Fribourg

Towards polymers with molecular auxeticity

Alizadeh, Mahshid ; Tennie, Iris K. ; Steiner, Ullrich ; Kilbinger, Andreas F. M.

In: CHIMIA International Journal for Chemistry, 2019, vol. 73, no. 1, p. 25–28

For many decades, it has been challenging to synthesize auxetic materials at the molecular level. Auxetic materials exhibit counterintuitive behavior; they expand perpendicularly to the direction in which they are stretched. An aromatic macrocycle containing a sequence of N-substituted and N-unsubstituted amides was designed to resemble the re-entrant structure found in macromolecular auxetic...

Université de Fribourg

Catalytic living ring-opening metathesis polymerization with Grubbs’ second- and third-generation catalysts

Yasir, Mohammad ; Liu, Peng ; Tennie, Iris K. ; Kilbinger, Andreas F. M.

In: Nature Chemistry, 2019, vol. 11, no. 5, p. 488–494

In a conventional living ring-opening metathesis polymerization (ROMP), an equal number of ruthenium complexes to the number of polymer chains synthesized are required. This can lead to high loadings of ruthenium complexes when aiming for shorter polymers. Here, a reversible chain-transfer agent was used to produce living ROMP polymers from norbornene derivatives using catalytic amounts of...

Università della Svizzera italiana

Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine

Corti, Davide ; Suguitan Jr., Amorsolo ; Pinna, Debora ; Silacci, Chiara ; Fernandez-Rodriguez, Blanca M. ; Vanzetta, Fabrizia ; Santos, Celia ; Luke, Catherine J. ; Torres-Velez, Fernando J. ; Temperton, Nigel J. ; Weiss, Robin A. ; Sallusto, Federica ; Subbarao, Kanta ; Lanzavecchia, Antonio

In: The Journal of clinical investigation, 2010, vol. 120, no. 5, p. 1663-1673

The target of neutralizing antibodies that protect against influenza virus infection is the viral protein HA. Genetic and antigenic variation in HA has been used to classify influenza viruses into subtypes (H1–H16). The neutralizing antibody response to influenza virus is thought to be specific for a few antigenically related isolates within a given subtype. However, while heterosubtypic...