000009231 001__ 9231
000009231 005__ 20131002113823.0
000009231 0248_ $$aoai:doc.rero.ch:20080507144309-YC$$punifr$$ppostprint$$prero_explore$$zcdu34$$zthesis_urn$$zreport$$zthesis$$zcdu1$$zbook$$zjournal$$zcdu16$$zpreprint$$zcdu616$$zdissertation
000009231 041__ $$aeng
000009231 080__ $$a616
000009231 100__ $$aInderbitzin, D. Th.$$uDepartment of General Surgery, Hôpital Cantonal Fribourg, Switzerland
000009231 245__ $$9eng$$aEnhanced tumour growth and impaired cellular antitumoural defence in hepatic colorectal carcinoma metastasis in rats after laparoscopy compared to open surgery
000009231 269__ $$c2008-02-05
000009231 520__ $$9eng$$aBackground  This study aims to assess postoperative hepatic growth of colorectal adenocarcinoma metastasis and peritumoural macrophage counts after laparoscopy in an experimental animal model. Methods Thirty male syngenic WAG/Rij rats were randomised into two surgical groups: laparoscopy (LS; <i>n</i> = 15) using CO₂ at 12 mmHg and laparotomy (LT; <i>n</i> = 15; negative control) during an operating time of 90 min. At 45 min after setup, CC531s colon adenocarcinoma cells were injected into two liver lobes. Postoperative tumour volumes were determined by abdominal magnetic resonance imaging (MRI) and computed three-dimensional volumetry. Peritumoural macrophages were counted by local stereology using a confocal laser-scanning fluorescence microscope. Results  The median postoperative tumour volume was significantly higher after LS in both lobes (L): after 10, 15 and 20 days in L2 and L5: 24/12, 54/38, 275/62 mm³ and 0/0, 15/11, 55/24 mm³ (LS/LT). Significantly fewer peritumoural macrophages were found after LS at all postoperative time points (Mann–Whitney: <i>p</i>< 0.05). Conclusions Increased hepatic growth of colorectal adenocarcinoma metastasis and impaired cellular antitumoural defence after LS cast doubt on the use of LS in colorectal cancer and needs further clinical investigation.
000009231 700__ $$aMarti, G. R.$$uDepartment of Histology and Embryology, Faculty of Medicine, University of Fribourg, Switzerland
000009231 700__ $$aEichenberger, S.$$uDepartment of Histology and Embryology, Faculty of Medicine, University of Fribourg, Switzerland
000009231 700__ $$aHoogewoud, H.-M.$$uDepartment of Radiology, Hôpital Cantonal Fribourg, Switzerland
000009231 700__ $$aKraehenbuehl, L.$$uDepartment of General Surgery, Hôpital Cantonal Fribourg, Switzerland - Department of Visceral Surgery, Lindenhof Spital, Berne, Switzerland
000009231 773__ $$g2008/15/4/p$$tAnnals of Surgical Oncology
000009231 775__ $$gPublished version$$ohttp://dx.doi.org/10.1245/s10434-007-9801-1
000009231 8564_ $$fmarti_etg.pdf$$qapplication/pdf$$s306359$$uhttp://doc.rero.ch/record/9231/files/marti_etg.pdf$$yorder:1$$zpdf
000009231 918__ $$aFaculté des sciences$$bDécanat, Ch. du Musée 6A, 1700 Fribourg$$cMédecine
000009231 919__ $$aUniversité de Fribourg$$bFribourg$$ddoc.support@rero.ch
000009231 980__ $$aPOSTPRINT$$bUNIFR$$fART_JOURNAL
000009231 990__ $$a20080507144309-YC