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Repair of the injured spinal cord, a joint approach of basic and clinical research

  • Buchli, Anita D. Brain Research Institute, University and ETH Zurich, Switzerland
  • Rouiller, Eric M. Department of Medicine, Unit of Physiology, University of Fribourg, Fribourg, Switzerland
  • Mueller, Roland Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland
  • Dietz, Volker Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland
  • Schwab, Martin E. Brain Research Institute, University and ETH Zurich, Switzerland
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    2007
Published in:
  • Neurodegenerative Diseases. - 2007, vol. 4, no. 1, p. 51-56
spinal cord injury
Nogo-A
axonal regeneration
functional recovery
neural plasticity
animal models
clinical trials
English The myelin protein Nogo-A is a potent inhibitor of neurite outgrowth in the central nervous system, thus contributing to the incapacity of fiber tracts in the adult spinal cord to regenerate after injury. In this review we report on a joint approach of different research groups to develop a therapy applying anti-Nogo-A antibodies to the injured spinal cord. While basic researchers took the initiative to provide means of neutralizing the inhibitory effect of Nogo-A and demonstrated enhanced fiber growth, regeneration and functional recovery both in rodent and primate models, clinical groups and rehabilitation engineers have sought to translate this novel strategy into a clinical setting.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biological sciences
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/300345
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