Faculté des sciences

The Synthesis of a Pyrazol Analogon of Porphobilinogen with the Help of the Mukaiyama Aldol Reaction

Chaperon, André ; Bertschy, Hugo ; Franz-Schrumpf, Anne-Laurence ; Hugelet, Bertrand ; Neels, Antonia ; Stoeckli-Evans, Helen ; Neier, Reinhard

In: Chimia, 2003, vol. 57, p. 601-606

The synthesis of a pyrazol analogon of porphobilinogen is described. The Mukaiyama crossed aldol reaction is the key step of our approach. The retrosynthetic analysis follows the mechanism for the biosynthesis of porphobilinogen initially proposed by Shemin. Plus

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    Summary
    The synthesis of a pyrazol analogon of porphobilinogen is described. The Mukaiyama crossed aldol reaction is the key step of our approach. The retrosynthetic analysis follows the mechanism for the biosynthesis of porphobilinogen initially proposed by Shemin.