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Modeling equilibrium clusters in lysozyme solutions

  • Cardinaux, Frédéric Department of Physics, University of Fribourg, Switzerland - Current address: Physik der weichen Materie, IPkM, Heinrich-Heine-Universität Düsseldorf, Germany
  • Stradner, Anna Department of Physics, University of Fribourg, Switzerland
  • Schurtenberger, Peter Department of Physics, University of Fribourg, Switzerland
  • Sciortino, F. Dipartimento di Fisica and CNR-INFM-SOFT, Università di Roma La Sapienza - Rome, Italy
  • Zaccarelli, E. Dipartimento di Fisica and CNR-INFM-SOFT, Università di Roma La Sapienza - Rome, Italy
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    09.02.2007
Published in:
  • Europhysics Letters. - 2007, vol. 77, no. 4, p. 48004
Proteins
X-ray scattering
Computer simulation of liquid structure
English We present a combined experimental and numerical study of the equilibrium cluster formation in globular-protein solutions under no-added salt conditions. We show that a cluster phase emerges as a result of a competition between a long-range screened Coulomb repulsion and a short-range attraction. A simple effective potential, in which electrostatic repulsion is fixed by experimental conditions and attraction is modeled with a generalized Lennard-Jones potential, accounts in a remarkable way for the wavevector dependence of the X-ray scattering structure factor.
Faculty
Faculté des sciences et de médecine
Department
Département de Physique
Language
  • English
Classification
Physics
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/300174
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