Faculté des sciences

Modeling equilibrium clusters in lysozyme solutions

Cardinaux, Frédéric ; Stradner, Anna ; Schurtenberger, Peter ; Sciortino, F. ; Zaccarelli, E.

In: Europhysics Letters, 2007, vol. 77, no. 4, p. 48004

We present a combined experimental and numerical study of the equilibrium cluster formation in globular-protein solutions under no-added salt conditions. We show that a cluster phase emerges as a result of a competition between a long-range screened Coulomb repulsion and a short-range attraction. A simple effective potential, in which electrostatic repulsion is fixed by experimental conditions... Plus

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    Summary
    We present a combined experimental and numerical study of the equilibrium cluster formation in globular-protein solutions under no-added salt conditions. We show that a cluster phase emerges as a result of a competition between a long-range screened Coulomb repulsion and a short-range attraction. A simple effective potential, in which electrostatic repulsion is fixed by experimental conditions and attraction is modeled with a generalized Lennard-Jones potential, accounts in a remarkable way for the wavevector dependence of the X-ray scattering structure factor.