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Influence of TOR kinase on lifespan in C. elegans

Vellai, Tibor ; Takacs-Vellai, Krisztina ; Zhang, Yue ; Kovacs, Attila L. ; Orosz, László ; Müller, Fritz

In: Nature, 2003, vol. 426, p. 620

The group of enzymes known as TOR (for 'target of rapamycin') kinases regulates cell growth and proliferation in response to nutrients and hormone-dependent mitogenic signals1, 2. Here we show that TOR deficiency in the nematode Caenorhabditis elegans more than doubles its natural lifespan. This new function for TOR signalling in ageing control may represent a link between... More

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    Title
    • Influence of TOR kinase on lifespan in C. elegans
    Author
    • Vellai, Tibor. Department of Biology, University of Fribourg, Switzerland
    • Takacs-Vellai, Krisztina. Department of Biology, University of Fribourg, Switzerland
    • Zhang, Yue. Department of Biology, University of Fribourg, Switzerland
    • Kovacs, Attila L.. Department of General Zoology, Eötvös Loránd University, Budapest, Hungary
    • Orosz, László. Department of Genetics, Eötvös Loránd University, Budapest, Hungary - Agricultural Biotechnology Centre, Gödöllö, Hungary
    • Müller, Fritz. Department of Biology, University of Fribourg, Switzerland
    Document Type
    • Postprint
    Publication Date
    • 2003-12-11
    Classification
    • Biology
    OAI-PMH Identifier
    • oai:doc.rero.ch:20060927140409-YO
    Submission No.
    • 20060927140409-YO
    Summary
    The group of enzymes known as TOR (for 'target of rapamycin') kinases regulates cell growth and proliferation in response to nutrients and hormone-dependent mitogenic signals1, 2. Here we show that TOR deficiency in the nematode Caenorhabditis elegans more than doubles its natural lifespan. This new function for TOR signalling in ageing control may represent a link between nutrition, metabolism and longevity.