Faculté des sciences

Nogo-A–specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates

Freund, Patrick ; Schmidlin, Eric ; Wannier, Thierry ; Bloch, Jocelyne ; Mir, Anis ; Schwab, Martin E ; Rouiller, Eric M

In: Nature Medicine, 2006/12/

In rodents, after spinal lesion, neutralizing the neurite growth inhibitor Nogo-A promotes axonal sprouting and functional recovery. To evaluate this treatment in primates, 12 monkeys were subjected to cervical lesion. Recovery of manual dexterity and sprouting of corticospinal axons were enhanced in monkeys treated with Nogo-A–specific antibody as compared to monkeys treated with control... Plus

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    Summary
    In rodents, after spinal lesion, neutralizing the neurite growth inhibitor Nogo-A promotes axonal sprouting and functional recovery. To evaluate this treatment in primates, 12 monkeys were subjected to cervical lesion. Recovery of manual dexterity and sprouting of corticospinal axons were enhanced in monkeys treated with Nogo-A–specific antibody as compared to monkeys treated with control antibody.