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Journal article

mPer1 and mPer2 mutant mice show regular spatial and contextual learning in standardized tests for hippocampus-dependent learning

  • Zueger, M. Central Institute of Mental Health Mannheim (ZI), University of Heidelberg, Germany
  • Urani, A. Central Institute of Mental Health Mannheim (ZI), University of Heidelberg, Germany
  • Chourbaji, S. Central Institute of Mental Health Mannheim (ZI), University of Heidelberg, Germany
  • Zacher, C. Central Institute of Mental Health Mannheim (ZI), University of Heidelberg, Germany
  • Lipp, H. P. Institute of Anatomy, University of Zürich-Irchel, Zürich, Switzerland
  • Albrecht, Urs Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
  • Spanagel, R. Central Institute of Mental Health Mannheim (ZI), University of Heidelberg, Germany
  • Wolfer, D. P. Institute of Anatomy, University of Zürich-Irchel, Zürich, Switzerland
  • Gass, P. Central Institute of Mental Health Mannheim (ZI), University of Heidelberg, Germany
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    2006
Published in:
  • Journal of Neural Transmission. - 2006, vol. 113, no. 3, p. 347-356
Clock genes
Hippocampus
Learning
Knockout mice
English Learning and memory, like most physiological processes, seem to be under the control of circadian rhythm. The recently cloned mPer1 and mPer2 genes play an important role in the regulation of the circadian rhythm. In this study, we tested mPer1 and mPer2 mutant mice in two different learning and memory paradigms, a water-maze place navigation task and contextual fear conditioning. In both learning tests, the hippocampus is critically involved. None of these learning types were affected by the mutations, suggesting that mPer1 and mPer2 do not play a major role in the regulation of hippocampus- dependent learning and memory.
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Medicine
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/299925
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