Faculté des sciences

Phosphoinositide 3-kinase γ mediates Jun kinase activation via its lipid-kinase activity

Pietrucha, Regina ; Rubio, Ignacio ; Wymann, Matthias P. ; Wetzker, Reinhard

In: Advances in Enzyme Regulation, 2004, vol. 44 (1), p. 299-308

Phosphoinositide 3-kinases (PI3K) are bifunctional enzymes expressing lipid- and protein-kinase activities. PI3K lipid kinase is involved in the control of cell motility, survival and other cellular reactions. Recent data point to specific signaling functions of PI3K protein-kinase activities. The PI3K species g has been shown to stimulate major signaling paths to the protein kinases Erk, JNK and... More

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    Summary
    Phosphoinositide 3-kinases (PI3K) are bifunctional enzymes expressing lipid- and protein-kinase activities. PI3K lipid kinase is involved in the control of cell motility, survival and other cellular reactions. Recent data point to specific signaling functions of PI3K protein-kinase activities. The PI3K species g has been shown to stimulate major signaling paths to the protein kinases Erk, JNK and PKB, in COS-7 cells. The present work was aimed to decipher the signaling reactions involved in the control of JNK activity by PI3Kg. Using functionally defined mutants we demonstrate an essential role of PI3Kg lipid-kinase activity for JNK stimulation. Together with recent findings these data evidence differential effects of PI3Kg protein- and lipidkinase activities on Erk, JNK and PKB signaling pathways.