Fulltext

Characterization of the collagen component of cartilage repair tissue of the talus with quantitative MRI: comparison of T2 relaxation time measurements with a diffusion-weighted double-echo steady-state sequence (dwDESS)

Kretzschmar, M. ; Bieri, O. ; Miska, M. ; Wiewiorski, M. ; Hainc, N. ; Valderrabano, V. ; Studler, U.

In: European Radiology, 2015, vol. 25, no. 4, p. 980-986

Ajouter à la liste personnelle
    Titre
    • Characterization of the collagen component of cartilage repair tissue of the talus with quantitative MRI: comparison of T2 relaxation time measurements with a diffusion-weighted double-echo steady-state sequence (dwDESS)
    Auteur
    • Kretzschmar, M.. Department of Radiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    • Bieri, O.. Division of Radiological Physics, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    • Miska, M.. Department of Orthopedics, University Hospital, Heidelberg, Germany
    • Wiewiorski, M.. Department of Orthopedic Surgery, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    • Hainc, N.. Department of Radiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    • Valderrabano, V.. Department of Orthopedic Surgery, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    • Studler, U.. Department of Radiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • European Radiology, 2015, vol. 25, no. 4, p. 980-986. Springer Berlin Heidelberg
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:333124
    Summary
    Objectives: The purpose of this study was to characterize the collagen component of repair tissue (RT) of the talus after autologous matrix-induced chondrogenesis (AMIC) using quantitative T2 and diffusion-weighted imaging. Methods: Mean T2 values and diffusion coefficients of AMIC-RT and normal cartilage of the talus of 25 patients with posttraumatic osteochondral lesions and AMIC repair were compared in a cross-sectional design using partially spoiled steady-state free precession (pSSFP) for T2 quantification, and diffusion-weighted double-echo steady-state (dwDESS) for diffusion measurement. RT and cartilage were graded with modified Noyes and MOCART scores on morphological sequences. An association between follow-up interval and quantitative MRI measures was assessed using multivariate regression, after stratifying the cohort according to time interval between surgery and MRI. Results: Mean T2 of the AMIC-RT and cartilage were 43.1ms and 39.1ms, respectively (p = 0.26). Mean diffusivity of the RT (1.76μm2/ms) was significantly higher compared to normal cartilage (1.46μm2/ms) (p = 0.0092). No correlation was found between morphological and quantitative parameters. RT diffusivity was lowest in the subgroup with follow-up >28months (p = 0.027). Conclusions: Compared to T2-mapping, dwDESS demonstrated greater sensitivity in detecting differences in the collagen matrix between AMIC-RT and cartilage. Decreased diffusivity in patients with longer follow-up times may indicate an increased matrix organization of RT. Key Points : • MRI is used to assess morphology of the repair tissue during follow-up. • Quantitative MRI allows an estimation of biochemical properties of the repair tissue. • Differences between repair tissue and cartilage were more significant with dwDESS than T2 mapping.