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Journal article

Nanomaterials and the human lung: what is known and what must be deciphered to realise their potential advantages?

  • Jud, Corinne Adolphe Merkle Institute, University of Fribourg, Switzerland
  • Clift, Martin J. D. Adolphe Merkle Institute, University of Fribourg, Switzerland
  • Petri-Fink, Alke Adolphe Merkle Institute, University of Fribourg, Switzerland - Chemistry Department, University of Fribourg, Switzerland
  • Rothen-Rutishauser, Barbara Adolphe Merkle Institute, University of Fribourg, Switzerland - Respiratory Medicine, Bern University Hospital, Inselspital, Switzerland
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    27.02.2013
Published in:
  • Swiss Medical Weekly. - 2013, vol. 143, no. 0910, p. w13758
Nanomaterials
Lung cell interaction
Lung models
In vitro
Epithelial airway barrier
Endocytosis
Risk assessment
English Due to the constant expansion within the nanotechnology industry in the last decade, nanomaterials are omnipresent in society today. Nanotechnology-based products have numerous different applications ranging from electronic (e.g., advanced memory chips) to industrial (e.g., coatings or composites) to biomedical (e.g., drug delivery systems, diagnostics). Although these new nanomaterials can be found in many “everyday” products, their effects on the human body have still to be investigated in order to identify not only their risk, but also their potential benefits towards human health. Since the lung is commonly thought to be the main portal of entry into the human body for nanomaterials released within the environment, this review will attempt to summarise the current knowledge and understanding of how nanomaterials interact with the respiratory tract. Furthermore, the advantages and disadvantages of different experimental model systems that are commonly used to study this exposure route to the human body will be discussed.
Faculty
Faculté des sciences et de médecine
Department
Département de Chimie
Language
  • English
Classification
Medicine
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/303095
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