Epidemiology of Carbapenemase-Producing Klebsiella pneumoniae in a Hospital, Portugal
- Aires-de-Sousa, Marta Escola Superior de Saúde da Cruz Vermelha Portuguesa, Lisbon, Portugal - Université de Fribourg, Fribourg, Switzerland
- Ortiz de la Rosa, José Manuel Université de Fribourg, Fribourg, Switzerland
- Gonçalves, Maria Luísa Hospital SAMS, Lisbon, Portugal
- Pereira, Ana Luísa Hospital SAMS, Lisbon, Portugal
- Nordmann, Patrice Université de Fribourg, Fribourg, Switzerland
- Poirel, Laurent Université de Fribourg, Fribourg, Switzerland
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2019
Published in:
- Emerging Infectious Diseases. - 2019, vol. 25, no. 9, p. 1632–1638
English
We aimed to provide updated epidemiologic data on carbapenem-resistant Klebsiella pneumoniae in Portugal by characterizing all isolates (N = 46) recovered during 2013– 2018 in a 123-bed hospital in Lisbon. We identified blaKPC-3 (n = 36), blaOXA-181 (n = 9), and blaGES-5 (n = 8) carbapenemase genes and observed co-occurrence of blaKPC-3 and blaGES-5 in 7 isolates. A single GES-5–producing isolate co-produced the extended-spectrum β-lactamase BEL-1; both corresponding genes were co- located on the same ColE1-like plasmid. The blaOXA-181 gene was always located on an IncX3 plasmid, whereas blaKPC-3 was carried on IncN, IncFII, IncFIB, and IncFIIA plasmid types. The 46 isolates were distributed into 13 pulsotypes and 9 sequence types. All isolates remained susceptible to ceftazidime/avibactam, but some exhibited reduced antimicrobial susceptibility (MIC = 3 mg/L).
- Faculty
- Faculté des sciences et de médecine
- Department
- Médecine 3ème année
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 327448
- DOI 10.3201/eid2509.190656
- Persistent URL
- https://folia.unifr.ch/unifr/documents/308217
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