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The VEINES-QOL/Sym questionnaire is a reliable and valid disease-specific quality of life measure for deep vein thrombosis in elderly patients

Méan, M. ; Limacher, A. ; Kahn, S. ; Aujesky, D.

In: Quality of Life Research, 2014, vol. 23, no. 9, p. 2463-2471

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    Titre
    • The VEINES-QOL/Sym questionnaire is a reliable and valid disease-specific quality of life measure for deep vein thrombosis in elderly patients
    Auteur
    • Méan, M.. Division of General Internal Medicine, Department of General Internal Medicine, Bern University Hospital, Inselspital, 3010, Bern, Switzerland
    • Limacher, A.. CTU Bern, Department of Clinical Research, and Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland
    • Kahn, S.. Centre for Clinical Epidemiology, Jewish General Hospital, Montreal, QC, Canada
    • Aujesky, D.. Division of General Internal Medicine, Department of General Internal Medicine, Bern University Hospital, Inselspital, 3010, Bern, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Quality of Life Research, 2014, vol. 23, no. 9, p. 2463-2471. Springer International Publishing
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:326358
    Summary
    Purpose: To prospectively evaluate the psychometric properties of the Venous Insufficiency Epidemiological and Economic Study (VEINES-QOL/Sym) questionnaire, an instrument to measure disease-specific quality of life and symptoms in elderly patients with deep vein thrombosis (DVT), and to validate a German version of the questionnaire. Methods: In a prospective multicenter cohort study of patients aged ≥65years with acute venous thromboembolism, we used standard psychometric tests and criteria to evaluate the reliability, validity, and responsiveness of the VEINES-QOL/Sym in patients with acute symptomatic DVT. We also performed an exploratory factor analysis. Results: Overall, 352 French- and German-speaking patients were enrolled (response rate of 87%). Both language versions of the VEINES-QOL/Sym showed good acceptability (missing data, floor and ceiling effects), reliability (internal consistency, item-total and inter-item correlations), validity (convergent, discriminant, known-groups differences), and responsiveness to clinical change over time in elderly patients with DVT. The exploratory factor analysis of the VEINES-QOL/Sym suggested three underlying dimensions: limitations in daily activities, DVT-related symptoms, and psychological impact. Conclusions: The VEINES-QOL/Sym questionnaire is a practical, reliable, valid, and responsive instrument to measure quality of life and symptoms in elderly patients with DVT and can be used with confidence in prospective studies to measure outcomes in such patients.