Fulltext

Physiologic and hematologic concerns of rotary blood pumps: what needs to be improved?

Pirbodaghi, Tohid ; Asgari, Siavash ; Cotter, Chris ; Bourque, Kevin

In: Heart Failure Reviews, 2014, vol. 19, no. 2, p. 259-266

Ajouter à la liste personnelle
    Titre
    • Physiologic and hematologic concerns of rotary blood pumps: what needs to be improved?
    Auteur
    • Pirbodaghi, Tohid. Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland
    • Asgari, Siavash. Department of Surgery-Cardiac Section, School of Medicine, Yale University, New Haven, CT, USA
    • Cotter, Chris. Thoratec Corporation, Burlington, MA, USA
    • Bourque, Kevin. Thoratec Corporation, Burlington, MA, USA
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Heart Failure Reviews, 2014, vol. 19, no. 2, p. 259-266. Springer US; http://www.springer-ny.com
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:325657
    Summary
    Over the past few decades, advances in ventricular assist device (VAD) technology have provided a promising therapeutic strategy to treat heart failure patients. Despite the improved performance and encouraging clinical outcomes of the new generation of VADs based on rotary blood pumps (RBPs), their physiologic and hematologic effects are controversial. Currently, clinically available RBPs run at constant speed, which results in limited control over cardiac workload and introduces blood flow with reduced pulsatility into the circulation. In this review, we first provide an update on the new challenges of mechanical circulatory support using rotary pumps including blood trauma, increased non-surgical bleeding rate, limited cardiac unloading, vascular malformations, end-organ function, and aortic valve insufficiency. Since the non-physiologic flow characteristic of these devices is one of the main subjects of scientific debate in the literature, we next emphasize the latest research regarding the development of a pulsatile RBP. Finally, we offer an outlook for future research in the field.