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Head Motion Parameters in fMRI Differ Between Patients with Mild Cognitive Impairment and Alzheimer Disease Versus Elderly Control Subjects

Haller, Sven ; Monsch, Andreas ; Richiardi, Jonas ; Barkhof, Frederik ; Kressig, Reto ; Radue, Ernst

In: Brain Topography, 2014, vol. 27, no. 6, p. 801-807

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    Titre
    • Head Motion Parameters in fMRI Differ Between Patients with Mild Cognitive Impairment and Alzheimer Disease Versus Elderly Control Subjects
    Auteur
    • Haller, Sven. Service Neuro-diagnostique et Neuro-interventionnel, Department of Imaging and Medical Informatics, University Hospitals of Geneva, Rue Gabrielle Perret-Gentil 4, 1211, Geneva 14, Switzerland
    • Monsch, Andreas. Memory Clinic, University Center for Medicine of Aging Basel, Felix Platter Hospital, Basel, Switzerland
    • Richiardi, Jonas. Functional Imaging in Neuropsychiatric Disorders Laboratory, Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA
    • Barkhof, Frederik. Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, the Netherlands
    • Kressig, Reto. University Center for Medicine of Aging Basel, Felix Platter Hospital, Basel, Switzerland
    • Radue, Ernst. Medical Image Analysis Center MIAC, University Hospitals of Basel, Basel, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Brain Topography, 2014, vol. 27, no. 6, p. 801-807. Springer US; http://www.springer-ny.com
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:325606
    Summary
    Motion artifacts are a well-known and frequent limitation during neuroimaging workup of cognitive decline. While head motion typically deteriorates image quality, we test the hypothesis that head motion differs systematically between healthy controls (HC), amnestic mild cognitive impairment (aMCI) and Alzheimer disease (AD) and consequently might contain diagnostic information. This prospective study was approved by the local ethics committee and includes 28 HC (age 71.0±6.9years, 18 females), 15 aMCI (age 67.7±10.9years, 9 females) and 20 AD (age 73.4±6.8years, 10 females). Functional magnetic resonance imaging (fMRI) at 3T included a 9min echo-planar imaging sequence with 180 repetitions. Cumulative average head rotation and translation was estimated based on standard fMRI preprocessing and compared between groups using receiver operating characteristic statistics. Global cumulative head rotation discriminated aMCI from controls [p<0.01, area under curve (AUC) 0.74] and AD from controls (p<0.01, AUC 0.73). The ratio of rotation z versus y discriminated AD from controls (p<0.05, AUC 0.71) and AD from aMCI (p<0.05, AUC of 0.75). Head motion systematically differs between aMCI/AD and controls. Since motion is not random but convoluted with diagnosis, the higher amount of motion in aMCI and AD as compared to controls might be a potential confounding factor for fMRI group comparisons. Additionally, head motion not only deteriorates image quality, yet also contains useful discriminatory information and is available for free as a "side product” of fMRI data preprocessing.