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Reference intervals for 24 laboratory parameters determined in 24-hour urine collections

Curcio, Raffaele ; Stettler, Helen ; Suter, Paolo M. ; Aksözen, Jasmin Barman ; Saleh, Lanja ; Spanaus, Katharina ; Bochud, Murielle ; Minder, Elisabeth ; von Eckardstein, Arnold

In: Clinical Chemistry and Laboratory Medicine (CCLM), 2016, vol. 54, no. 1, p. 105-116

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    Titre
    • Reference intervals for 24 laboratory parameters determined in 24-hour urine collections
    Auteur
    • Curcio, Raffaele. Institute for Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
    • Stettler, Helen. Clinic and Polyclinic of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
    • Suter, Paolo M.. Clinic and Polyclinic of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
    • Aksözen, Jasmin Barman. Institute of Laboratory Medicine, Stadtspital Triemli, Zurich, Switzerland
    • Saleh, Lanja. Institute for Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
    • Spanaus, Katharina. Institute for Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
    • Bochud, Murielle. Community Prevention Unit, Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland
    • Minder, Elisabeth. Institute of Laboratory Medicine, Stadtspital Triemli, Zurich, Switzerland
    • von Eckardstein, Arnold. Institute for Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Clinical Chemistry and Laboratory Medicine (CCLM), 2016, vol. 54, no. 1, p. 105-116. De Gruyter
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:325603
    Summary
    Background: Reference intervals for many laboratory parameters determined in 24-h urine collections are either not publicly available or based on small numbers, not sex specific or not from a representative sample. Methods: Osmolality and concentrations or enzymatic activities of sodium, potassium, chloride, glucose, creatinine, citrate, cortisol, pancreatic α-amylase, total protein, albumin, transferrin, immunoglobulin G, α1-microglobulin, α2-macroglobulin, as well as porphyrins and their precursors (δ-aminolevulinic acid and porphobilinogen) were determined in 241 24-h urine samples of a population-based cohort of asymptomatic adults (121 men and 120 women). For 16 of these 24 parameters creatinine-normalized ratios were calculated based on 24-h urine creatinine. The reference intervals for these parameters were calculated according to the CLSI C28-A3 statistical guidelines. Results: By contrast to most published reference intervals, which do not stratify for sex, reference intervals of 12 of 24 laboratory parameters in 24-h urine collections and of eight of 16 parameters as creatinine-normalized ratios differed significantly between men and women. For six parameters calculated as 24-h urine excretion and four parameters calculated as creatinine-normalized ratios no reference intervals had been published before. For some parameters we found significant and relevant deviations from previously reported reference intervals, most notably for 24-h urine cortisol in women. Ten 24-h urine parameters showed weak or moderate sex-specific correlations with age. Conclusions: By applying up-to-date analytical methods and clinical chemistry analyzers to 24-h urine collections from a large population-based cohort we provide as yet the most comprehensive set of sex-specific reference intervals calculated according to CLSI guidelines for parameters determined in 24-h urine collections.