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Oxygen regulates molecular mechanisms of cancer progression and metastasis

Gupta, Kartik ; Madan, Esha ; Sayyid, Muzzammil ; Arias-Pulido, Hugo ; Moreno, Eduardo ; Kuppusamy, Periannan ; Gogna, Rajan

In: Cancer and Metastasis Reviews, 2014, vol. 33, no. 1, p. 183-215

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    Titre
    • Oxygen regulates molecular mechanisms of cancer progression and metastasis
    Auteur
    • Gupta, Kartik. Experimental and Molecular Pediatric Cardiology, German Heart Center Munich at the Technical University Munich, Lazarettstrasse 36, 80636, Munich, Germany
    • Madan, Esha. Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012, Bern, Switzerland
    • Sayyid, Muzzammil. School of Veterinary Medicine, St. George's University, University Centre, St. George's, Grenada-WI
    • Arias-Pulido, Hugo. Clinical Research and Translational Therapeutics Lab, University of New Mexico Cancer Center, 87131, Albuquerque, NM, USA
    • Moreno, Eduardo. Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012, Bern, Switzerland
    • Kuppusamy, Periannan. Norris Cotton Cancer Center, Geisel School of Medicine, Dartmouth College, 03756, Lebanon, NH, USA
    • Gogna, Rajan. Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012, Bern, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Cancer and Metastasis Reviews, 2014, vol. 33, no. 1, p. 183-215. Springer US; http://www.springer-ny.com
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:325378
    Summary
    Oxygen is the basic molecule which supports life and it truly is "god's gift to life.” Despite its immense importance, research on "oxygen biology” has never received the light of the day and has been limited to physiological and biochemical studies. It seems that in modern day biology, oxygen research is summarized in one word "hypoxia.” Scientists have focused on hypoxia-induced transcriptomics and molecular-cellular alterations exclusively in disease models. Interestingly, the potential of oxygen to control the basic principles of biology like homeostatic maintenance, transcription, replication, and protein folding among many others, at the molecular level, has been completely ignored. Here, we present a perspective on the crucial role played by oxygen in regulation of basic biological phenomena. Our conclusion highlights the importance of establishing novel research areas like oxygen biology, as there is great potential in this field for basic science discoveries and clinical benefits to the society.