Secreted venom allergen-like proteins of helminths: Conserved modulators of host responses in animals and plants
- Wilbers, Ruud H. P. Laboratory of Nematology, Plant Sciences Group, Wageningen University and Research, Wageningen, The Netherlands
- Schneiter, Roger Division of Biochemistry, Department of Biology, University of Fribourg, Switzerland
- Holterman, Martijn H. M. Laboratory of Nematology, Plant Sciences Group, Wageningen University and Research, Wageningen, The Netherlands
- Drurey, Claire Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, UK
- Smant, Geert Laboratory of Nematology, Plant Sciences Group, Wageningen University and Research, Wageningen, The Netherlands
- Asojo, Oluwatoyin A. Department of Chemistry and Biochemistry, Hampton University, Hampton, Virginia, USA
- Maizels, Rick M. Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, UK
- Lozano-Torres, Jose L. Laboratory of Nematology, Plant Sciences Group, Wageningen University and Research, Wageningen, The Netherlands
-
18.10.2018
Published in:
- PLOS Pathogens. - 2018, vol. 14, no. 10, p. e1007300
English
Despite causing considerable damage to host tissue at the onset of parasitism, invasive helminths establish remarkably persistent infections in both animals and plants. Secretions released by these obligate parasites during host invasion are thought to be crucial for their persistence in infection. Helminth secretions are complex mixtures of molecules, most of which have unknown molecular targets and functions in host cells or tissues. Although the habitats of animal- and plant-parasitic helminths are very distinct, their secretions share the presence of a structurally conserved group of proteins called venom allergen-like proteins (VALs). Helminths abundantly secrete VALs during several stages of parasitism while inflicting extensive damage to host tissue. The tight association between the secretion of VALs and the onset of parasitism has triggered a particular interest in this group of proteins, as improved knowledge on their biological functions may assist in designing novel protection strategies against parasites in humans, livestock, and important food crops.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Biologie
- Language
-
- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
-
- RERO DOC 323812
- DOI 10.1371/journal.ppat.1007300
- Persistent URL
- https://folia.unifr.ch/unifr/documents/307274
Statistics
Document views: 22
File downloads:
- sch_sva.pdf: 40