Fulltext

Hormone replacement therapy, mammography screening and changing age-specific incidence rates of breast cancer: an ecological study comparing two European populations

Verkooijen, H. ; Koot, V. ; Fioretta, G. ; van der Heiden, M. ; Schipper, M. ; Rapiti, E. ; Peeters, P. ; Peterse, J. ; Bouchardy, C.

In: Breast Cancer Research and Treatment, 2008, vol. 107, no. 3, p. 389-395

Aggiungi alla tua lista
    Titre
    • Hormone replacement therapy, mammography screening and changing age-specific incidence rates of breast cancer: an ecological study comparing two European populations
    Auteur
    • Verkooijen, H.. Geneva Cancer Registry, Institute for Social and Preventive Medicine, Geneva University, 55 Boulevard de la Cluse, 1205, Geneva, Switzerland
    • Koot, V.. Comprehensive Cancer Center Middle Netherlands, Catharijnesingel 55, 3511, Utrecht, GD, The Netherlands
    • Fioretta, G.. Geneva Cancer Registry, Institute for Social and Preventive Medicine, Geneva University, 55 Boulevard de la Cluse, 1205, Geneva, Switzerland
    • van der Heiden, M.. Comprehensive Cancer Center Middle Netherlands, Catharijnesingel 55, 3511, Utrecht, GD, The Netherlands
    • Schipper, M.. Department of Pathology, University Medical Center Utrecht, P.O. Box 85500, 3508, Utrecht, GA, The Netherlands
    • Rapiti, E.. Geneva Cancer Registry, Institute for Social and Preventive Medicine, Geneva University, 55 Boulevard de la Cluse, 1205, Geneva, Switzerland
    • Peeters, P.. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, P.O. Box 85500, 3508, Utrecht, GA, The Netherlands
    • Peterse, J.. Department of Pathology, Netherlands Cancer Institute, Plesmanlaan 121, 1066, Amsterdam, CX, The Netherlands
    • Bouchardy, C.. Geneva Cancer Registry, Institute for Social and Preventive Medicine, Geneva University, 55 Boulevard de la Cluse, 1205, Geneva, Switzerland
    Type de document
    • Postprint
    Langue
    • Inglese
    Publié dans
    • Breast Cancer Research and Treatment, 2008, vol. 107, no. 3, p. 389-395. Springer US; http://www.springer-ny.com
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:321882
    Summary
    Background: In 2003, for the first time, US breast cancer incidence rates have fallen. Experts argue whether this is due to the reduced uptake of screening mammography or to lower use of Hormone Replacement Therapy (HRT). This study aims to disentangle the respective impact of screening and HRT on age-incidence rates and histology of breast cancer, by comparing two populations with comparably high levels of screening mammography, but with different prevalence of HRT. Methods: We included all invasive breast cancers recorded at the Geneva cancer registry (n=4,909) and the Netherlands Cancer Registry (n=152,428) between 1989-2003. We compared age-specific incidence rates and trends in histological subtyping between the two populations. Results: Between 1989-1991, incidence rates increased with age in both populations. In 2001-2003, women aged 60-64years showed highest incidence rates in Geneva, while in the Netherlands incidence rates continued to increase with age. The annual increase in ductal cancer incidence was similar in the Netherlands (2.3%) and Geneva (2.5%), but the annual increase in lobular cancer was sharper in Geneva (10%) than in the Netherlands (5%). Conclusion: The sharp differences in age distribution and histological subtyping of breast cancer between two European populations are not attributable to screening, since both populations have a high uptake of mammography screening. Since the prevalence of HRT use is very high in Geneva and rather low in the Netherlands, HRT may explain these discrepancies. However, other etiological factors and differences in histological assessment may also have played a role