Vascular Dynamics of Cerebral Gliomas Investigated with Selective Catheter Angiography, Perfusion CT and MRI = Durchblutung zerebraler Gliome. Eine Studie mit DSA, Perfusions-CT und MRT

Wiest, Roland ; Schaer, Ralph ; Reinert, Michael ; von Bredow, Ferdinand ; El Koussy, Marwan ; Remonda, Luca ; Schroth, Gerhard ; Ozdoba, Christoph ; Slotboom, Johannes

In: Clinical Neuroradiology, 2008, vol. 18, no. 2, p. 98-106

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    Purpose:: To assess if intratumoral blood circulation parameters from dynamic susceptibility contrast (DSC) MRI and dynamic CT deliver comparable results and to compare tumor-related changes in regional cerebral blood flow (rCBF) and regional cerebral blood volume (rCBV) with arterial, intratumoral, and venous transition detected with digital subtraction angiography (DSA). Patients and Methods:: Ten patients with cerebral gliomas were prospectively studied with DSC-MRI, dynamic CT and DSA. Tumor areas were segmented and perfusion maps for rCBF, rCBV, and mean transit time (MTT) were computed from DSC-MRI and dynamic CT. Arterial circulation time (ACT), intermediate circulation time (ICT), and venous appearance time (VAT) were measured with DSA. Asymmetry indices (AIs) were calculated for MRI- and CT-based perfusion values, for ICT and VAT and compared among each other. Results:: DSC-MRI and dynamic CT yielded comparable AI values for rCBF (MRI: 39.5 ± 20.4, CT: 36.0 ± 17.9, Pearson's correlation r2 = 0.91) and rCBV (MRI: 44.6 ± 20.9 vs. CT: 40.9 ± 16.3, r2 = 0.84). The MTT AI (MRI: -4.7 ± 11.2 vs. CT: -0.5 ± 10.4, r2 = 0.47) showed only a weak correlation. ICT correlated with rCBV (ICT: 38.4 ± 14.7, r2 = 0.59, and dynamic CT: r2 = 0.81) and VAT with rCBF (VAT: 31.7 ± 17.6, r2 = 0.73, and dynamic CT: r2 = 0.87), but not with MTT. Conclusion:: CT and MRI methods provide consistent information about tumor vascularity of cerebral gliomas in accordance with DSA