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Human endothelial dysfunction: EDRFs

Flammer, Andreas ; Lüscher, Thomas

In: Pflügers Archiv - European Journal of Physiology, 2010, vol. 459, no. 6, p. 1005-1013

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    Titre
    • Human endothelial dysfunction: EDRFs
    Auteur
    • Flammer, Andreas. Cardiovascular Center, Cardiology University Hospital Zurich, Zurich, Switzerland
    • Lüscher, Thomas. Cardiovascular Center, Cardiology University Hospital Zurich, Zurich, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • Pflügers Archiv - European Journal of Physiology, 2010, vol. 459, no. 6, p. 1005-1013. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:321588
    Summary
    Since the detection of nitric oxide two and a half decades ago, there has been an incredible boost in endothelial function research, which is fascinating the research community. Physiologically, endothelial cells synthesize a number of vasoactive substances. In particular, several endothelium-derived relaxing factors (EDRFs) have been characterized, whereby nitric oxide is the most important. In humans, endothelial dysfunction is one of the first clinically detectable alterations in the development of atherosclerosis and is characterized by an imbalance in the release of vasoactive substances. Thus, it is the aim of this article to give an overview about endothelial function in humans, to summarize the different possibilities to assess endothelial function in this species, and to give an overview of the role of EDRFs in different cardiovascular diseases