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Magnetic Resonance Imaging for the in Vivo Evaluation of Gastric-Retentive Tablets

Steingoetter, Andreas ; Weishaupt, Dominik ; Kunz, Patrick ; Mäder, Karsten ; Lengsfeld, Hans ; Thumshirn, Miriam ; Boesiger, Peter ; Fried, Michael ; Schwizer, Werner

In: Pharmaceutical Research, 2003, vol. 20, no. 12, p. 2001-2007

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    Titel
    • Magnetic Resonance Imaging for the in Vivo Evaluation of Gastric-Retentive Tablets
    Autor
    • Steingoetter, Andreas. Biophysics group, Institute of Biomedical Engineering, University and ETH Zurich Gloriastrasse, 35 CH-8092, Zurich, Switzerland
    • Weishaupt, Dominik. Department of Radiology, University Hospital Zurich, Switzerland
    • Kunz, Patrick. F. Hoffmann-LaRoche, Basel, Switzerland
    • Mäder, Karsten. F. Hoffmann-LaRoche, Basel, Switzerland
    • Lengsfeld, Hans. F. Hoffmann-LaRoche, Basel, Switzerland
    • Thumshirn, Miriam. Department of Gastroenterology, University Hospital Zurich, Switzerland
    • Boesiger, Peter. Biophysics group, Institute of Biomedical Engineering, University and ETH Zurich Gloriastrasse, 35 CH-8092, Zurich, Switzerland
    • Fried, Michael. Department of Gastroenterology, University Hospital Zurich, Switzerland
    • Schwizer, Werner. Department of Gastroenterology, University Hospital Zurich, Switzerland
    Dokumententyp
    • Postprint
    Sprache
    • Englisch
    Veröffentlicht in
    • Pharmaceutical Research, 2003, vol. 20, no. 12, p. 2001-2007. Kluwer Academic Publishers-Plenum Publishers
    Andere elektronische Ausgabe
    OAI-PMH-ID
    • oai:doc.rero.ch:321545
    Summary
    Purpose. To develop a magnetic resonance imaging (MRI) technique for assessing in vivo properties of orally ingested gastric-retentive tablets under physiologic conditions. Methods. Tablets with different floating characteristics (tablet A-C) were marked with superparamagnetic Fe3O4 particles to analyze intragastric tablet position and residence time in human volunteers. Optimal Fe3O4 concentration was determined in vitro. Intragastric release characteristic of one slow-release tablet (tablet D) was analyzed by embedding gadolinium chelates (Gd-DOTA) as a drug model into the tablet. All volunteers underwent MRI in the sitting position. Tablet performance was analyzed in terms of relative position of tablet to intragastric meal level (with 100% at meal surface), intragastric residence time (min) and Gd-DOTA distribution volume (% of meal volume). Results. Intragastric tablet floating performance and residence time of tablets (tablet A-D) as well as the intragastric Gd-DOTA distribution of tablet D could be monitored using MRI. Tablet floating performance was different between the tablets (A, 93%(95 − 9%); B, 80%(80 − 68%); C, 38%(63 − 32%); p < 0.05). The intragastric distribution volume of Gd-DOTA was 19.9% proximally and 35.5% distally. Conclusions. The use of MRI allows the assessment of galenic properties of orally ingested tablets in humans in seated position