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Concomitant statin use does not impair the clinical outcome of patients with diffuse large B cell lymphoma treated with rituximab-CHOP

Samaras, Panagiotis ; Heider, Helen ; Haile, Sarah ; Petrausch, Ulf ; Schaefer, Niklaus ; Siciliano, Raffaele ; Meisel, Alexander ; Mischo, Axel ; Zweifel, Martin ; Knuth, Alexander ; Stenner-Liewen, Frank ; Renner, Christoph

In: Annals of Hematology, 2010, vol. 89, no. 8, p. 783-787

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    Titre
    • Concomitant statin use does not impair the clinical outcome of patients with diffuse large B cell lymphoma treated with rituximab-CHOP
    Auteur
    • Samaras, Panagiotis. Department of Oncology, University Hospital Zürich, Rämistrasse 100, 8091, Zürich, Switzerland
    • Heider, Helen. Department of Oncology, University Hospital Zürich, Rämistrasse 100, 8091, Zürich, Switzerland
    • Haile, Sarah. Biostatistics Unit, Institute of Social and Preventive Medicine, University of Zurich, Zurich, Switzerland
    • Petrausch, Ulf. Department of Oncology, University Hospital Zürich, Rämistrasse 100, 8091, Zürich, Switzerland
    • Schaefer, Niklaus. Department of Oncology, University Hospital Zürich, Rämistrasse 100, 8091, Zürich, Switzerland
    • Siciliano, Raffaele. Medical Oncology, Triemli City Hospital, Zurich, Switzerland
    • Meisel, Alexander. Department of Oncology, University Hospital Zürich, Rämistrasse 100, 8091, Zürich, Switzerland
    • Mischo, Axel. Department of Oncology, University Hospital Zürich, Rämistrasse 100, 8091, Zürich, Switzerland
    • Zweifel, Martin. Department of Oncology, University Hospital Zürich, Rämistrasse 100, 8091, Zürich, Switzerland
    • Knuth, Alexander. Department of Oncology, University Hospital Zürich, Rämistrasse 100, 8091, Zürich, Switzerland
    • Stenner-Liewen, Frank. Department of Oncology, University Hospital Zürich, Rämistrasse 100, 8091, Zürich, Switzerland
    • Renner, Christoph. Department of Oncology, University Hospital Zürich, Rämistrasse 100, 8091, Zürich, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:321522
    Summary
    Preclinical data indicated a detrimental effect of statins on the anti-lymphoma activity of rituximab. We evaluated the impact of concomitant statin medication on the response and survival of patients with diffuse large B cell lymphoma (DLBCL) receiving rituximab-cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP) as first-line therapy. Medical histories of patients with DLBCL who were treated with R-CHOP as first-line therapy were assessed for concomitant statin use, response after completion of chemotherapy, event-free survival (EFS), and overall survival (OS). Furthermore, 2-[18F]fluor-2-deoxyglucose (FDG)-PET/CT results after completion of first-line therapy were compared between the groups. Overall, 145 patients with DLBCL treated with R-CHOP from January 2001 to December 2009 were analyzed. Twenty-one (15%) patients received statins throughout therapy. Five-year EFS was 67.3% in patients without statins compared with 79% in patients receiving statins during R-CHOP (HR, 0.47; 95% CI, 0.15-1.54, p = 0.2). Five-year OS was 81.4% for patients without statins compared with 93.3% for patients taking statins (HR, 0.58; 95% CI 0.07-4.55, p = 0.6). There were no statistically significant differences in the rates of complete remissions between the two groups (75% in the non-statin group versus 86% in the statin group, p = 0.45). A trend toward a lower rate of complete metabolic responses in FDG-PET/CT after chemotherapy was seen in patients without statin medication compared with the patients taking statins (84% versus 92%, p = 0.068). Concomitant statin use had no adverse impact on response to chemotherapy, EFS, and OS in patients treated with R-CHOP for DLBCL