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Matching between regional coronary vasodilator capacity and corresponding circumferential strain in individuals with normal and increasing body weight

Vincenti, Gabriella ; Ambrosio, Giuseppe ; Hyacinthe, Jean-Noël ; Quercioli, Alessandra ; Seimbille, Yann ; Mach, François ; Ratib, Osman ; Vallée, Jean-Paul ; Schindler, Thomas

In: Journal of Nuclear Cardiology, 2012, vol. 19, no. 4, p. 693-703

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    Title
    • Matching between regional coronary vasodilator capacity and corresponding circumferential strain in individuals with normal and increasing body weight
    Author
    • Vincenti, Gabriella. Division of Cardiology, Nuclear Cardiology and Cardiac PET/CT, Department of Specialities in Medicine, University Hospital of Geneva, 6th Floor, Rue Gabrielle-Perret-Gentil 4, 1211, Geneva, Switzerland
    • Ambrosio, Giuseppe. Division of Cardiology, School of Medicine, University of Perugia, Perugia, Italy
    • Hyacinthe, Jean-Noël. Divisions of Nuclear Medicine and Radiology, Department of Medical Imaging and Information Science, University Hospital of Geneva, Geneva, Switzerland
    • Quercioli, Alessandra. Division of Cardiology, Nuclear Cardiology and Cardiac PET/CT, Department of Specialities in Medicine, University Hospital of Geneva, 6th Floor, Rue Gabrielle-Perret-Gentil 4, 1211, Geneva, Switzerland
    • Seimbille, Yann. Divisions of Nuclear Medicine and Radiology, Department of Medical Imaging and Information Science, University Hospital of Geneva, Geneva, Switzerland
    • Mach, François. Division of Cardiology, Nuclear Cardiology and Cardiac PET/CT, Department of Specialities in Medicine, University Hospital of Geneva, 6th Floor, Rue Gabrielle-Perret-Gentil 4, 1211, Geneva, Switzerland
    • Ratib, Osman. Divisions of Nuclear Medicine and Radiology, Department of Medical Imaging and Information Science, University Hospital of Geneva, Geneva, Switzerland
    • Vallée, Jean-Paul. Divisions of Nuclear Medicine and Radiology, Department of Medical Imaging and Information Science, University Hospital of Geneva, Geneva, Switzerland
    • Schindler, Thomas. Division of Cardiology, Nuclear Cardiology and Cardiac PET/CT, Department of Specialities in Medicine, University Hospital of Geneva, 6th Floor, Rue Gabrielle-Perret-Gentil 4, 1211, Geneva, Switzerland
    Document Type
    • Postprint
    OAI-PMH Identifier
    • oai:doc.rero.ch:320136
    Summary
    Background: To define the relationship between regional coronary vasodilator capacity and myocardial circumferential strain at rest in normal weight, overweight, and obese individuals with normal global left-ventricular function. Methods and Results: Myocardial blood flow at rest and during pharmacologic vasodilation was measured with 13N-ammonia PET/CT in mL/g/minute in normal weight control (CON, n=12), overweight (OW, n=10), and obese individuals (OB, n=10). In addition, resting myocardial function was evaluated as circumferential strain (Єc, %) by MRI. Global myocardial flow reserve (MFR) did not differ significantly between CON and OW (2.98±0.96 vs 2.70±0.66, P=.290), whereas it declined significantly in OB (1.98±1.04, P=.030). Further, global Єc (%) was comparable between CON, OW, and OB (−0.24±0.03, −0.23±0.02, and −0.23±0.04) but it was lowest in OB when normalized to the rate-pressure product (NЄc: −0.31±0.06, −0.32±0.05, and −0.26±0.08). When MFR of the three major coronary territories was correlated with corresponding Єc, a positive association was observed in CON (r=0.36, P=.030), in OW (r=0.54, P=.002), and also in OB when relating NЄc to coronary vascular resistance during pharmacologic vasodilation (r=−0.46, P=.010). Conclusions: Higher coronary vasodilator capacity is related to corresponding regional circumferential strain at rest in non-obese individuals, while this is also observed for reduced MFR in obesity