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Determinants of vessel contrast in BMI-adapted low dose CT coronary angiography with prospective ECG-triggering

Herzog, Bernhard ; Husmann, Lars ; Valenta, Ines ; Tay, Fabian ; Burkhard, Nina ; Gaemperli, Oliver ; Wyss, Christophe ; Landmesser, Ulf ; Kaufmann, Philipp

In: The International Journal of Cardiovascular Imaging, 2009, vol. 25, no. 6, p. 625-630

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    Title
    • Determinants of vessel contrast in BMI-adapted low dose CT coronary angiography with prospective ECG-triggering
    Author
    • Herzog, Bernhard. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Husmann, Lars. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Valenta, Ines. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Tay, Fabian. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Burkhard, Nina. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Gaemperli, Oliver. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Wyss, Christophe. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Landmesser, Ulf. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    • Kaufmann, Philipp. Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland
    Document Type
    • Postprint
    Language
    • English
    Published in
    • The International Journal of Cardiovascular Imaging, 2009, vol. 25, no. 6, p. 625-630. Springer Netherlands
    Other Version
    OAI-PMH Identifier
    • oai:doc.rero.ch:320066
    Summary
    We evaluated the determinants of vessel contrast in prospectively ECG-triggered CT coronary angiography (CTCA). Seventy patients underwent low-dose CTCA using Body Mass Index (BMI)-adapted tube parameters and a fixed contrast material bolus. Contrast to noise ratio (CNR) was calculated from contrast (between coronaries and perivascular tissue) and image noise (standard deviation of aortic attenuation). Cardiac output (CO) was calculated from gated 99mTc-tetrofosmin-SPECT. Mean radiation dose was 2.13±0.69mSv. Image noise was not affected by BMI (r=0.1, P=0.36), while CNR was inversely related to body surface area (BSA) (r=−0.5, P<0.001) and CO (r=−0.45, P<0.001). After successfully overcoming the impact of BMI on image noise by adapting tube parameters, CNR mainly depends on coronary vessel contrast. The latter reflects the dilution of the contrast material by blood volume and CO, which are both correlated to BSA. Therefore, BSA adapted contrast administration may help to compensate for this effect