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The role of COX-2 in rectal cancer treated with preoperative radiotherapy

Bouzourene, Hanifa ; Yan, Pu ; Sandmeier, Dominique ; Zouhair, Abderrahim ; Matter, Maurice ; Vuilleumier, Henri ; Coucke, Philippe

In: Virchows Archiv, 2008, vol. 452, no. 5, p. 499-505

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    Titre
    • The role of COX-2 in rectal cancer treated with preoperative radiotherapy
    Auteur
    • Bouzourene, Hanifa. Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Bugnon 25, CH 1011, Lausanne, Switzerland
    • Yan, Pu. Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Bugnon 25, CH 1011, Lausanne, Switzerland
    • Sandmeier, Dominique. Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Bugnon 25, CH 1011, Lausanne, Switzerland
    • Zouhair, Abderrahim. Department of Radiooncology, Centre Hospitalier Universitaire Vaudois, CH 1011, Lausanne, Switzerland
    • Matter, Maurice. Department of Surgery, Centre Hospitalier Universitaire Vaudois, CH 1011, Lausanne, Switzerland
    • Vuilleumier, Henri. Department of Surgery, Centre Hospitalier Universitaire Vaudois, CH 1011, Lausanne, Switzerland
    • Coucke, Philippe. Department of Radiation-Oncology, Hôpital Maisonneuve-Rosemont, 5415, Boulevard de l'Assomption, H1T 2M4, Montréal, QC, Canada
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:319762
    Summary
    Radiotherapy is one of the principal modalities of rectal cancer treatment, and the ability to predict radio resistance could potentially improve survival through a targeted treatment approach. Cyclooxygenase-2 (COX-2) may protect against damage by irradiation that would justify the use of COX-2 inhibitors. The purpose of this study was to investigate the potential role of COX-2 in tumor response and outcome of patients with rectal cancer treated preoperatively with radiotherapy. Using immunohistochemistry, we examined COX-2 expression in 88 surgical specimens of rectal cancer treated preoperatively and in 26 pretherapeutic biopsies. We tested whether COX-2 expression was correlated with clinico-pathologic parameters and with survival and local recurrence. COX-2 was expressed in 50% of the pretherapeutic tumor biopsies and in 88.6% of post-irradiated surgical samples. COX-2 expression was correlated only with enhanced tumor inflammation (p = 0.03) and with tumor volume exceeding 30cc (p = 0.05). COX-2 was not significantly correlated with patient survival, but none of the patients with COX-2 negative tumors did recur locally, whereas 80% of patients with local recurrences have COX-2 positive tumors. We conclude that COX-2 expression is overexpressed in the majority of rectal cancers treated with radiotherapy and likely plays a role in local relapse