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Diagnostic accuracy of contrast-enhanced FDG-PET/CT in primary staging of cutaneous malignant melanoma

Veit-Haibach, Patrick ; Vogt, Florian ; Jablonka, Robert ; Kuehl, Hilmar ; Bockisch, Andreas ; Beyer, Thomas ; Dahmen, Gerlinde ; Rosenbaum, Sandra ; Antoch, Gerald

In: European Journal of Nuclear Medicine and Molecular Imaging, 2009, vol. 36, no. 6, p. 910-918

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    Titre
    • Diagnostic accuracy of contrast-enhanced FDG-PET/CT in primary staging of cutaneous malignant melanoma
    Auteur
    • Veit-Haibach, Patrick. Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstrasse 55, 45122, Essen, Germany
    • Vogt, Florian. Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstrasse 55, 45122, Essen, Germany
    • Jablonka, Robert. Department of Dermatology, University Hospital Essen, Essen, Germany
    • Kuehl, Hilmar. Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstrasse 55, 45122, Essen, Germany
    • Bockisch, Andreas. Department of Nuclear Medicine, University Hospital Essen, Essen, Germany
    • Beyer, Thomas. Department of Nuclear Medicine, University Hospital Essen, Essen, Germany
    • Dahmen, Gerlinde. Institute of Medical Biometry and Statistics, University at Luebeck, Luebeck, Germany
    • Rosenbaum, Sandra. Department of Nuclear Medicine, University Hospital Essen, Essen, Germany
    • Antoch, Gerald. Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • European Journal of Nuclear Medicine and Molecular Imaging, 2009, vol. 36, no. 6, p. 910-918. Springer-Verlag
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:319519
    Summary
    Purpose: To evaluate the diagnostic accuracy of contrast-enhanced FDG-PET/CT (ce-PET/CT), PET-only, and CT-only in patients with newly diagnosed and resected cutaneous malignant melanoma. Methods: A final group of 56 patients (mean age 62years, range 23-86years; 29 women, 27 men) were staged with ce-PET/CT after resection of the primary tumour. Histopathology as well as clinical follow-up (mean 780days, range 102-1,390 days) served as the standards of reference. Differences between the staging modalities were tested for statistical significance with McNemar's test. Results: All imaging procedures provided low sensitivities in the detection of lymph nodes (sensitivity N-stage: PET/CT and PET-only 38.5%; CT-only 23.1%) and distant metastases (sensitivity M-stage: PET/CT 41.7%, PET-only 33.3%, CT-only 25.0%) in initial staging after resection of the primary tumour. No statistically significant differences were detected between the imaging procedures (p > 0.05). PET/CT resulted in an alteration in further treatment in two patients compared to PET-only and in four patients compared to CT-only. Conclusion: All imaging modalities had a low sensitivity on initial staging of patients with malignant melanoma. Thus, close patient follow-up must be considered mandatory