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Therapeutic impact of [18F]fluoride positron-emission tomography/computed tomography on patients with unclear foot pain

Fischer, Dorothee ; Maquieira, Gerardo ; Espinosa, Norman ; Zanetti, Marco ; Hesselmann, Rolf ; Johayem, Anass ; Hany, Thomas ; von Schulthess, Gustav ; Strobel, Klaus

In: Skeletal Radiology, 2010, vol. 39, no. 10, p. 987-997

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    Title
    • Therapeutic impact of [18F]fluoride positron-emission tomography/computed tomography on patients with unclear foot pain
    Author
    • Fischer, Dorothee. Department of Nuclear Medicine, University Hospital of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland
    • Maquieira, Gerardo. Foot and Ankle Surgery, Department of Orthopaedics, University of Zurich, Balgrist, Zurich, Switzerland
    • Espinosa, Norman. Foot and Ankle Surgery, Department of Orthopaedics, University of Zurich, Balgrist, Zurich, Switzerland
    • Zanetti, Marco. Department of Radiology, University of Zurich, Balgrist, Zurich, Switzerland
    • Hesselmann, Rolf. Department of Nuclear Medicine, University Hospital of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland
    • Johayem, Anass. Department of Nuclear Medicine, University Hospital of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland
    • Hany, Thomas. Department of Nuclear Medicine, University Hospital of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland
    • von Schulthess, Gustav. Department of Nuclear Medicine, University Hospital of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland
    • Strobel, Klaus. Department of Nuclear Medicine, University Hospital of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland
    Document Type
    • Postprint
    OAI-PMH Identifier
    • oai:doc.rero.ch:319330
    Summary
    Purpose: To evaluate the therapeutic impact of [18F]fluoride positron-emission tomography/computed tomography ([18F]fluoride PET/CT) imaging on patients with unclear foot pain. Methods: Twenty-eight patients were prospectively included in this study. Therapeutic management was defined by two experienced dedicated foot surgeons before and after [18F]fluoride PET/CT imaging. Twenty-six patients underwent cross-sectional imaging [CT, magnetic resonance (MR)] prior to PET/CT. A retrospective analysis of the magnetic resonance imaging (MRI) diagnoses was performed when a therapy change occurred after PET/CT imaging. Results: In 13/28 (46%) patients therapeutic management was changed due to PET/CT results. Management changes occurred in patients with the following diagnoses: os trigonum syndrome; sinus tarsi syndrome; os tibiale externum syndrome; osteoarthritis of several joints; non-consolidated fragments; calcaneo-navicular coalition; plantar fasciitis; insertional tendinopathy; suggestion of periostitis; neoarticulations between metatarsal bones. Os trigonum, os tibiale externum, subtalar osteoarthritis and plantar fasciitis were only seen to be active on PET/CT images but not on MR images. Conclusion: [18F]fluoride PET/CT has a substantial therapeutic impact on management in patients with unclear foot pain