Nuclear myocardial perfusion imaging with a novel cadmium-zinc-telluride detector SPECT/CT device: first validation versus invasive coronary angiography

Fiechter, Michael ; Ghadri, Jelena ; Kuest, Silke ; Pazhenkottil, Aju ; Wolfrum, Mathias ; Nkoulou, Rene ; Goetti, Robert ; Gaemperli, Oliver ; Kaufmann, Philipp

In: European Journal of Nuclear Medicine and Molecular Imaging, 2011, vol. 38, no. 11, p. 2025-2030

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    Purpose: We evaluated the diagnostic accuracy of attenuation corrected nuclear myocardial perfusion imaging (MPI) with a novel hybrid single photon emission computed tomography (SPECT)/CT device consisting of an ultrafast dedicated cardiac gamma camera with cadmium-zinc-telluride (CZT) solid-state semiconductor detectors integrated onto a multislice CT scanner to detect coronary artery disease (CAD). Invasive coronary angiography served as the standard of reference. Methods: The study population included 66 patients (79% men; mean age 63 ± 11years) who underwent 1-day 99mTc-tetrofosmin pharmacological stress/rest examination and angiography within 3months. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) as well as accuracy of the CT X-ray based attenuation corrected CZT MPI for detection of CAD (≥50% luminal narrowing) was calculated on a per-patient basis. Results: The prevalence of angiographic CAD in the study population was 82%. Sensitivity, specificity, PPV, NPV and accuracy were 87, 67, 92, 53 and 83%, respectively. Conclusion: In this first report on CZT SPECT/CT MPI comparison versus angiography we confirm a high accuracy for detection of angiographically documented CAD