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Method for performing cerebral perfusion-weighted MRI in neonates

Laswad, Tarek ; Wintermark, Pia ; Alamo, Leonor ; Moessinger, Adrien ; Meuli, Reto ; Gudinchet, François

In: Pediatric Radiology, 2009, vol. 39, no. 3, p. 260-264

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    Titre
    • Method for performing cerebral perfusion-weighted MRI in neonates
    Auteur
    • Laswad, Tarek. Radiology Department, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, 1011, Lausanne, Switzerland
    • Wintermark, Pia. Division of Neonatology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, 1011, Lausanne, Switzerland
    • Alamo, Leonor. Radiology Department, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, 1011, Lausanne, Switzerland
    • Moessinger, Adrien. Division of Neonatology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, 1011, Lausanne, Switzerland
    • Meuli, Reto. Radiology Department, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, 1011, Lausanne, Switzerland
    • Gudinchet, François. Radiology Department, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, 1011, Lausanne, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:319105
    Summary
    Cerebral perfusion-weighted imaging (PWI) in neonates is known to be technically difficult and there are very few published studies on its use in preterm infants. In this paper, we describe one convenient method to perform PWI in neonates, a method only recently used in newborns. A device was used to manually inject gadolinium contrast material intravenously in an easy, quick and reproducible way. We studied 28 newborn infants, with various gestational ages and weights, including both normal infants and those suffering from different brain pathologies. A signal intensity-time curve was obtained for each infant, allowing us to build perfusion maps. This technique offered a fast and easy method to manually inject a bolus gadolinium contrast material, which is essential in performing PWI in neonates. Cerebral PWI is technically feasible and reproducible in neonates of various gestational age and with various pathologies