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Acceptance of two liquid vitamin D3 formulations among mothers with newborn infants: a randomized, single-blind trial

Lava, Sebastiano ; Caccia, Giorgio ; Osmetti-Gianini, Silvia ; Simonetti, Giacomo ; Milani, Gregorio ; Falesi, Mattia ; Bianchetti, Mario

In: European Journal of Pediatrics, 2011, vol. 170, no. 12, p. 1559-1562

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    Title
    • Acceptance of two liquid vitamin D3 formulations among mothers with newborn infants: a randomized, single-blind trial
    Author
    • Lava, Sebastiano. Division of Pediatrics, Bellinzona and Mendrisio and University of Bern, Bern, Switzerland
    • Caccia, Giorgio. Division of Obstetrics and Gynecology, Mendrisio, Switzerland
    • Osmetti-Gianini, Silvia. Division of Pediatrics, Bellinzona and Mendrisio and University of Bern, Bern, Switzerland
    • Simonetti, Giacomo. Pediatric Nephrology, University Children's Hospital Bern and University of Bern, Bern, Switzerland
    • Milani, Gregorio. Division of Pediatrics, Bellinzona and Mendrisio and University of Bern, Bern, Switzerland
    • Falesi, Mattia. Division of Pediatrics, Bellinzona and Mendrisio and University of Bern, Bern, Switzerland
    • Bianchetti, Mario. Division of Pediatrics, Bellinzona and Mendrisio and University of Bern, Bern, Switzerland
    Document Type
    • Postprint
    OAI-PMH Identifier
    • oai:doc.rero.ch:319075
    Summary
    In Switzerland, children are prescribed 7.5-12.5μg per day of vitamin D3 dissolved in alcohol, but many families do not adhere to the recommendation. The aim of the trial was to compare the acceptance of vitamin D3 dissolved in alcohol or in medium-chain triglycerides among mothers of Swiss newborn infants. The acceptance was tested in 42 healthy newborn infants (20 girls and 22 boys) aged between 2 and 7days. Their neonatal body weight ranged between 2.225 and 4.150kg, and the gestational age between 36 1/7 and 41 3/7weeks. The blinded mothers rated the facial reaction of their children by pointing on a facial hedonic scale. Thirty eight of the 41 mothers, who brought the comparison to completion, assigned a better score to the oily preparation with no difference in the remaining three cases (P < 0.0001). The acceptance for the oily preparation was significantly better both among mothers whose babies were initially presented the alcoholic preparation and among mothers whose babies were initially presented the oily preparation. Furthermore, the acceptance for the oily preparation was better irrespective of gender of the infant or parity of the mother. In conclusion, from the perspective of mothers, Swiss newborn infants prefer the taste of the oily vitamin D3 preparation over the alcoholic preparation