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VZV retinal vasculitis without systemic infection: diagnosis and monitoring with quantitative polymerase chain reaction

Wimmersberger, Yves ; Gervaix, A. ; Baglivo, Edoardo

In: International Ophthalmology, 2010, vol. 30, no. 1, p. 73-75

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    Titre
    • VZV retinal vasculitis without systemic infection: diagnosis and monitoring with quantitative polymerase chain reaction
    Auteur
    • Wimmersberger, Yves. Clinique d'Ophtalmologie—Uveitis Department, Hôpitaux Universitaires de Genève, rue Alcide-Jentzer, 22, 1205, Geneva, Switzerland
    • Gervaix, A.. Department of Pediatrics, University Hospitals of Geneva, Geneva, Switzerland
    • Baglivo, Edoardo. Clinique d'Ophtalmologie—Uveitis Department, Hôpitaux Universitaires de Genève, rue Alcide-Jentzer, 22, 1205, Geneva, Switzerland
    Type de document
    • Postprint
    Langue
    • Anglais
    Publié dans
    • International Ophthalmology, 2010, vol. 30, no. 1, p. 73-75. Springer Netherlands
    Autre version électronique
    Identifiant OAI-PMH
    • oai:doc.rero.ch:319028
    Summary
    To report a case of unilateral varicella zoster virus (VZV) retinal vasculitis aspect in an immunocompetent child without systemic infection. Clinically, no signs of retinal necrosis or frosted branch vasculitis were present. This is an observational case report. Quantitative PCR was performed on the aqueous humor (AH) using primers specific for herpes virus (cytomegalovirus, Epstein-Barr virus, herpes simplex virus 1-2, and VZV). The patient was treated with intravenous acyclovir, intravitreous ganciclovir, and oral valacyclovir. A positive quantitative PCR result was found for VZV DNA (1.72×106 viral copies/ml) in the AH. After 6months, PCR of the AH was negative. Herpes viruses are involved in the pathogenesis of isolated retinal vasculitis. This case demonstrates that quantitative PCR is useful to detect viral DNA in AH and to monitor the viral activity and the therapeutic response