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MDC1: The art of keeping things in focus

Jungmichel, Stephanie ; Stucki, Manuel

In: Chromosoma, 2010, vol. 119, no. 4, p. 337-349

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    Titre
    • MDC1: The art of keeping things in focus
    Auteur
    • Jungmichel, Stephanie. Institute of Veterinary Biochemistry and Molecular Biology, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland
    • Stucki, Manuel. Institute of Veterinary Biochemistry and Molecular Biology, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland
    Type de document
    • Postprint
    Classification
    • Santé
    Identifiant OAI-PMH
    • oai:doc.rero.ch:318650
    Summary
    The chromatin structure is important for recognition and repair of DNA damage. Many DNA damage response proteins accumulate in large chromatin domains flanking sites of DNA double-strand breaks. The assembly of these structures—usually termed DNA damage foci—is primarily regulated by MDC1, a large nuclear mediator/adaptor protein that is composed of several distinct structural and functional domains. Here, we are summarizing the latest discoveries about the mechanisms by which MDC1 mediates DNA damage foci formation, and we are reviewing the considerable efforts taken to understand the functional implication of these structures