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Image fusion of coronary CT angiography and cardiac perfusion MRI: a pilot study

Stolzmann, Paul ; Alkadhi, Hatem ; Scheffel, Hans ; Hennemuth, Anja ; Kuehnel, Caroline ; Baumueller, Stephan ; Kozerke, Sebastian ; Falk, Volkmar ; Marincek, Borut ; Donati, Olivio

In: European Radiology, 2010, vol. 20, no. 5, p. 1174-1179

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    Title
    • Image fusion of coronary CT angiography and cardiac perfusion MRI: a pilot study
    Author
    • Stolzmann, Paul. Institute of Diagnostic Radiology, University Hospital Zurich, Zurich, Switzerland
    • Alkadhi, Hatem. Institute of Diagnostic Radiology, University Hospital Zurich, Zurich, Switzerland
    • Scheffel, Hans. Institute of Diagnostic Radiology, University Hospital Zurich, Zurich, Switzerland
    • Hennemuth, Anja. Fraunhofer MEVIS, Bremen, Germany
    • Kuehnel, Caroline. Fraunhofer MEVIS, Bremen, Germany
    • Baumueller, Stephan. Institute of Diagnostic Radiology, University Hospital Zurich, Zurich, Switzerland
    • Kozerke, Sebastian. Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland
    • Falk, Volkmar. Clinic for Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland
    • Marincek, Borut. Institute of Diagnostic Radiology, University Hospital Zurich, Zurich, Switzerland
    • Donati, Olivio. Institute of Diagnostic Radiology, University Hospital Zurich, Zurich, Switzerland
    Document Type
    • Postprint
    OAI-PMH Identifier
    • oai:doc.rero.ch:318595
    Summary
    Objective: To develop a tool for the image fusion of computed tomography coronary angiography (CTCA) and cardiac magnetic resonance imaging (CMR). Methods: Surface representations and volume-rendered images from fused CTCA/CMR data of five patients with significant coronary artery disease (CAD) on CTCA and perfusion deficits on CMR were generated using a newly developed software prototype. The spatial relationship of significant coronary artery stenosis at CTCA and myocardial defects at CMR was evaluated. Results: Registration of CTCA and CMR images was possible in all patients. The comprehensive three-dimensional visualisation of fused CTCA and CMR data accurately demonstrated the relationship between coronary artery stenoses and myocardial defects in all patients. Conclusion: The introduced tool enables image fusion of CTCA and CMR data sets and allows for correct superposition of the coronary arteries derived from CTCA onto the corresponding myocardial segments derived from CMR. The method facilitates the comprehensive assessment of the functionally relevant CAD by the exact allocation of culprit coronary stenoses to corresponding myocardial defects at a low radiation dose