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Expression of the breast differentiation antigen NY-BR-1 in a phyllodes tumor of the vulva

Giger, Olivier ; Lacoste, Elena ; Honegger, Christoph ; Padberg, Barbara ; Moch, Holger ; Varga, Zsuzsanna

In: Virchows Archiv, 2007, vol. 450, no. 4, p. 471-474

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    Titre
    • Expression of the breast differentiation antigen NY-BR-1 in a phyllodes tumor of the vulva
    Auteur
    • Giger, Olivier. Institute of Surgical Pathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091, Zurich, Switzerland
    • Lacoste, Elena. Department of Gynecology, Hospital Uster, Uster, Switzerland
    • Honegger, Christoph. Department of Gynecology, Hospital Uster, Uster, Switzerland
    • Padberg, Barbara. Institute of Surgical Pathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091, Zurich, Switzerland
    • Moch, Holger. Institute of Surgical Pathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091, Zurich, Switzerland
    • Varga, Zsuzsanna. Institute of Surgical Pathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091, Zurich, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:317934
    Summary
    We describe a phyllodes tumor of borderline malignancy in the labium majus of a 49-year-old woman. The histogenetic origin of phyllodes tumors in the vulva is controversial. Strong immunoreactivity for NY-BR-1, a novel breast differentiation antigen, was demonstrated within the epithelial components of the phyllodes tumor. A similar expression pattern was observed in mammary-like glands of the vulva. These findings provide further evidence that phyllodes tumors of the vulva might derive from mammary-like glands in the labium majus or from ectopic breast tissue