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Sporadic Creutzfeldt-Jakob disease : A comparison of pathological findingsand diffusion weighted imaging

Russmann, Heike ; Vingerhoets, Francois ; Miklossy, Judith ; Maeder, Philippe ; Glatzel, Markus ; Aguzzi, Adriano ; Bogousslavsky, Julien

In: Journal of Neurology, 2005, vol. 252, no. 3, p. 338-342

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    Titre
    • Sporadic Creutzfeldt-Jakob disease
      A comparison of pathological findingsand diffusion weighted imaging
    Auteur
    • Russmann, Heike. Dept. of Neurology, Centre Hospitalier Universitaire Vaudois, Route de Bugnon 11, CH-1011, Lausanne, Switzerland
    • Vingerhoets, Francois. Dept. of Neurology, Centre Hospitalier Universitaire Vaudois, Route de Bugnon 11, CH-1011, Lausanne, Switzerland
    • Miklossy, Judith. Dept. of Pathology, Centre Hospitalier Universitaire Lausanne, Lausanne, Switzerland
    • Maeder, Philippe. Dep. of Radiology, Centre Hospitalier Universitaire Lausanne, Lausanne, Switzerland
    • Glatzel, Markus. Dept. of Pathology, Centre Hospitalier Universitaire Zurich, Zurich, Switzerland
    • Aguzzi, Adriano. Dept. of Pathology, Centre Hospitalier Universitaire Zurich, Zurich, Switzerland
    • Bogousslavsky, Julien. Dept. of Neurology, Centre Hospitalier Universitaire Vaudois, Route de Bugnon 11, CH-1011, Lausanne, Switzerland
    Type de document
    • Postprint
    Identifiant OAI-PMH
    • oai:doc.rero.ch:317810
    Summary
    To investigate a possible relationship between the severity of pathological and radiological lesions in diffusion-weighted MRI (DWI) we compared DWI findings from 6 sequential brain MRI scans with pathological features of numerous tissue blocks of different cortical and subcortical regions in a case of autopsy-proven sporadic CJD. Whereas DWI and pathological examination revealed multifocal, cortical and deep hyperintensities at corresponding localizations, no correlation between the degree of severity of radiologically visible and pathological damage was found. The characteristic focal involvement and extension of lesions of the cortex and the basal ganglia bilaterally shown by DWI may be an argument for the spreading of the disease per contiguitatem